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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3baz NAP Hydroxyphenylpyruvate reductase 1.1.1.237

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 1.298
4xyb NDPFormate dehydrogenase / 0.906
2dbz NAPGlyoxylate reductase 1.1.1.26 0.870
2dbq NAPGlyoxylate reductase 1.1.1.26 0.831
2dbr NAPGlyoxylate reductase 1.1.1.26 0.829
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.793
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.786
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.779
5j23 A2RPutative 2-hydroxyacid dehydrogenase / 0.769
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.767
3kb6 NADD-lactate dehydrogenase / 0.763
2gsd NADFormate dehydrogenase / 0.754
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.751
4z0p NDPNAD-dependent dehydrogenase / 0.750
2nad NADFormate dehydrogenase / 0.748
3qrw NDPPutative ketoacyl reductase 1.3.1 0.743
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.740
4c4o NADSADH / 0.730
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.727
4bms NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.720
4lcj NADC-terminal-binding protein 2 / 0.719
3mje NDPAmphB / 0.718
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.717
2gn8 NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 0.714
3two NDPMannitol dehydrogenase / 0.713
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.712
2dc1 NADProbable L-aspartate dehydrogenase / 0.707
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.706
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.705
4weq NAPNAD-dependent dehydrogenase / 0.705
4oaq NDPR-specific carbonyl reductase / 0.703
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.700
3phi NDPShikimate dehydrogenase (NADP(+)) / 0.699
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.693
4ejm NAPPutative zinc-binding dehydrogenase / 0.693
4hxy NDPPlm1 / 0.692
1yqd NAPSinapyl alcohol dehydrogenase / 0.691
4tqg NDPPutative dTDP-d-glucose 4 6-dehydratase / 0.691
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.690
4imp NDPPolyketide synthase extender modules 3-4 / 0.690
4dbz NDPPutative ketoacyl reductase 1.3.1 0.689
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.688
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.686
3wle NAD(R)-specific carbonyl reductase / 0.686
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.686
1x7h NDPPutative ketoacyl reductase 1.3.1 0.684
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.681
2vhx NADAlanine dehydrogenase 1.4.1.1 0.681
3ptz NADUDP-glucose 6-dehydrogenase 1.1.1.22 0.681
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.681
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.681
1ipe NDPTropinone reductase 2 1.1.1.236 0.679
3ai2 NDPNADPH-sorbose reductase / 0.679
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.677
3tox NAPPutative oxidoreductase / 0.677
1w8d NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.676
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.676
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.676
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.676
3u4c NDPNADPH-dependent reductase BacG / 0.675
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.675
1oaa NAPSepiapterin reductase 1.1.1.153 0.674
2jah NDPClavaldehyde dehydrogenase / 0.674
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.674
3tn7 NJPShort-chain alcohol dehydrogenase / 0.673
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.673
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.672
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.671
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.671
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.671
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.669
1ofg NDPGlucose--fructose oxidoreductase 1.1.99.28 0.669
1ybm NAPUncharacterized protein At5g02240 / 0.667
4b4o NDPEpimerase family protein SDR39U1 / 0.667
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.666
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.665
1zh8 NAPUncharacterized protein / 0.665
3l77 NJPShort-chain alcohol dehydrogenase / 0.665
2voj NADAlanine dehydrogenase 1.4.1.1 0.662
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.661
4k28 NADShikimate dehydrogenase family protein / 0.661
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.660
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.660
4j49 NADUncharacterized protein / 0.660
1w4z NAPPutative ketoacyl reductase 1.3.1 0.659
2gcg NDPGlyoxylate reductase/hydroxypyruvate reductase 1.1.1.79 0.657
1cf2 NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.656
2vq3 NAPMetalloreductase STEAP3 / 0.656
1xq6 NAPUncharacterized protein At5g02240 / 0.655
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.655
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.655
5d2e NAPMlnE / 0.655
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.654
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.654
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.653
1yqx NAPSinapyl alcohol dehydrogenase / 0.653
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.653
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.652
3ai3 NDPNADPH-sorbose reductase / 0.652
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.650
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.650