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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zoq 5ID Mitogen-activated protein kinase 3 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.907
4e5i 0N9Polymerase acidic protein / 0.744
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.698
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.697
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.690
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.689
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.686
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.684
1i44 ACPInsulin receptor 2.7.10.1 0.676
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.675
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.673
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.671
4lgg VGGProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.671
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.664
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.663
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.662
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.662
2pml ANPUncharacterized protein / 0.661
4e5f 0N7Polymerase acidic protein / 0.660
3b2t M33Fibroblast growth factor receptor 2 / 0.659
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.658
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.657
3bht MFRCyclin-dependent kinase 2 2.7.11.22 0.656
2pzr ACPFibroblast growth factor receptor 2 / 0.654
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.654
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.654
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.654
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.653
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.652
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.652
5dn3 ATPAurora kinase A 2.7.11.1 0.652
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.650
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.650