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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yk2 YJW Heat shock protein HSP 90-alpha

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2yk2 YJWHeat shock protein HSP 90-alpha / 0.958
2yjw YJWHeat shock protein HSP 90-alpha / 0.842
2yi6 6QMHeat shock protein HSP 90-alpha / 0.799
4egk RDCHeat shock protein HSP 90-alpha / 0.793
2vci 2GJHeat shock protein HSP 90-alpha / 0.786
3eko PYUHeat shock protein HSP 90-alpha / 0.782
2uwd 2GGHeat shock protein HSP 90-alpha / 0.766
3ekr PY9Heat shock protein HSP 90-alpha / 0.761
2ye4 2FYHeat shock protein HSP 90-alpha / 0.759
2bsm BSMHeat shock protein HSP 90-alpha / 0.756
2vcj 2EQHeat shock protein HSP 90-alpha / 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2xab VHDHeat shock protein HSP 90-alpha / 0.742
2bre KJ2ATP-dependent molecular chaperone HSP82 / 0.739
2hkj RDCType 2 DNA topoisomerase 6 subunit B / 0.736
3k97 4CDHeat shock protein HSP 90-alpha / 0.730
3k98 1RCHeat shock protein HSP 90-alpha / 0.729
3k99 PFTHeat shock protein HSP 90-alpha / 0.718
3hhu 819Heat shock protein HSP 90-alpha / 0.715
2cct 2E1Heat shock protein HSP 90-alpha / 0.708
4mpe PV8[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.703
4mpn PV0[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.703
2wer RDCATP-dependent molecular chaperone HSP82 / 0.702
2iwu NP5ATP-dependent molecular chaperone HSP82 / 0.701
2yi5 YI5Heat shock protein HSP 90-alpha / 0.700
1u0z RDCEndoplasmin / 0.696
4b7p 9UNHeat shock protein HSP 90-alpha / 0.690
2bt0 CT5Heat shock protein HSP 90-alpha / 0.689
2yei XQIHeat shock protein HSP 90-alpha / 0.688
2cgf P2NATP-dependent molecular chaperone HSP82 / 0.686
2yi7 BZ8Heat shock protein HSP 90-alpha / 0.686
2xhx T5MHeat shock protein HSP 90-alpha / 0.678
2iwx M1SATP-dependent molecular chaperone HSP82 / 0.675
4ce2 BO5ATP-dependent molecular chaperone HSP82 / 0.674
3inw JZBHeat shock protein HSP 90-alpha / 0.670
2iws NP4ATP-dependent molecular chaperone HSP82 / 0.668
4e5f 0N7Polymerase acidic protein / 0.660
2pc4 ASP_TRP_ASNFructose-bisphosphate aldolase 4.1.2.13 0.653
2ccu 2D9Heat shock protein HSP 90-alpha / 0.650
4mpc PV2[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.650