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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2yaa ATP Death-associated protein kinase 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2yaa ATPDeath-associated protein kinase 2 / 0.931
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.777
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.777
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.755
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.748
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.731
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.720
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.719
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.715
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.713
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.711
1mq4 ADPAurora kinase A 2.7.11.1 0.707
4qny ANPMitogen activated protein kinase, putative / 0.702
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.700
2dwb ANPAurora kinase A 2.7.11.1 0.700
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.699
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.699
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.699
3t8o ATPRhodopsin kinase / 0.697
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.697
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.697
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.697
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.696
5dos ATPAurora kinase A 2.7.11.1 0.696
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.695
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.694
5eg3 ACPFibroblast growth factor receptor 2 / 0.694
2olc ADPMethylthioribose kinase 2.7.1.100 0.693
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.692
4o4f ATPKinase / 0.692
5dt3 ATPAurora kinase A 2.7.11.1 0.692
1ol5 ADPAurora kinase A 2.7.11.1 0.691
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.691
5dt4 ATPAurora kinase A 2.7.11.1 0.690
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.687
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.687
5dr2 ATPAurora kinase A 2.7.11.1 0.687
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.685
5dnr ATPAurora kinase A 2.7.11.1 0.683
4o4e ATPKinase / 0.682
4ceg ADPAurora kinase A 2.7.11.1 0.681
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.677
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.676
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.676
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.674
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.673
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.670
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.670
1ol6 ATPAurora kinase A 2.7.11.1 0.669
4xlv ACPInsulin receptor 2.7.10.1 0.669
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.668
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.668
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.668
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.668
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.667
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.667
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.667
1cm8 ANPMitogen-activated protein kinase 12 / 0.666
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.665
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.665
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.662
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.660
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.660
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.659
1m0w ANPGlutathione synthetase 6.3.2.3 0.658
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.658
3orm AGSSerine/threonine protein kinase / 0.658
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.657
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.657
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.657
4c3r ACPAurora kinase A 2.7.11.1 0.657
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.656
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.656
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.656
4gyi ADPUncharacterized protein / 0.655
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.655
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.655
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.654
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.654
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.653
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.652
3llt ANPProtein serine/threonine kinase-1 / 0.652
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.651
4o4d ATPKinase / 0.651
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.650
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.650