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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xs0 ANP Mitogen-activated protein kinase 8 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.940
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.763
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.742
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.728
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.727
2py3 ACPFibroblast growth factor receptor 2 / 0.716
2pz5 ACPFibroblast growth factor receptor 2 / 0.705
2pzp ACPFibroblast growth factor receptor 2 / 0.704
3cly ACPFibroblast growth factor receptor 2 / 0.701
4xlv ACPInsulin receptor 2.7.10.1 0.697
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.695
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.693
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.692
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.688
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.686
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.685
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.683
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.681
4j98 ACPFibroblast growth factor receptor 2 / 0.680
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.676
3bu5 ATPInsulin receptor 2.7.10.1 0.675
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.672
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.672
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.671
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.668
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.665
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.664
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.664
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
1cm8 ANPMitogen-activated protein kinase 12 / 0.661
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.661
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.661
2g2f AGSTyrosine-protein kinase ABL1 2.7.10.2 0.661
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.659
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.659
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.659
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.659
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.658
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.658
2if8 ADPInositol polyphosphate multikinase 2.7.1.151 0.658
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
1ol5 ADPAurora kinase A 2.7.11.1 0.655
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.655
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.655
3rv4 ADPBiotin carboxylase 6.3.4.14 0.652
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.651
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.651
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
5eg3 ACPFibroblast growth factor receptor 2 / 0.651
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.650
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.650
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.650