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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wxv WXV Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 1.039
2fvd LIACyclin-dependent kinase 2 2.7.11.22 0.761
2p33 J07Mitogen-activated protein kinase 10 2.7.11.24 0.751
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.743
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.730
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.723
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.717
2bts U32Cyclin-dependent kinase 2 2.7.11.22 0.714
5ap7 SVEDual specificity protein kinase TTK 2.7.12.1 0.710
3cgo JNOMitogen-activated protein kinase 10 2.7.11.24 0.709
3r9o Z71Cyclin-dependent kinase 2 2.7.11.22 0.706
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.704
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.703
3rpy 27ZCyclin-dependent kinase 2 2.7.11.22 0.702
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.699
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.692
2vtj LZ4Cyclin-dependent kinase 2 2.7.11.22 0.690
3s1h 56ZCyclin-dependent kinase 2 2.7.11.22 0.688
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.686
2c6t DT5Cyclin-dependent kinase 2 2.7.11.22 0.682
3tiz 3TICyclin-dependent kinase 2 2.7.11.22 0.681
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.680
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.680
2c6i DT1Cyclin-dependent kinase 2 2.7.11.22 0.679
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.679
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.679
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.679
1ckp PVBCyclin-dependent kinase 2 2.7.11.22 0.678
1z5m LI83-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.678
1y8y CT7Cyclin-dependent kinase 2 2.7.11.22 0.677
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.676
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.675
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.674
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.674
4eor 4SPCyclin-dependent kinase 2 2.7.11.22 0.674
2yac 937Serine/threonine-protein kinase PLK1 2.7.11.21 0.673
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.672
4fv6 E57Mitogen-activated protein kinase 1 2.7.11.24 0.672
1ykr 628Cyclin-dependent kinase 2 2.7.11.22 0.671
1y91 CT9Cyclin-dependent kinase 2 2.7.11.22 0.669
4bcn T9NCyclin-dependent kinase 2 2.7.11.22 0.669
1oir HDYCyclin-dependent kinase 2 2.7.11.22 0.668
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.667
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.664
2iw8 4SPCyclin-dependent kinase 2 2.7.11.22 0.663
2c6k DT2Cyclin-dependent kinase 2 2.7.11.22 0.662
3rk9 09ZCyclin-dependent kinase 2 2.7.11.22 0.662
1h1s 4SPCyclin-dependent kinase 2 2.7.11.22 0.661
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.661
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.661
1oiq HDUCyclin-dependent kinase 2 2.7.11.22 0.660
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.660
4bcq TJFCyclin-dependent kinase 2 2.7.11.22 0.660
3r9h Z67Cyclin-dependent kinase 2 2.7.11.22 0.659
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.659
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.658
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.658
2w05 FRTCyclin-dependent kinase 2 2.7.11.22 0.658
3rk7 08ZCyclin-dependent kinase 2 2.7.11.22 0.658
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.658
1pxo CK7Cyclin-dependent kinase 2 2.7.11.22 0.656
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.656
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.656
2r3l SCWCyclin-dependent kinase 2 2.7.11.22 0.656
4fv7 E94Mitogen-activated protein kinase 1 2.7.11.24 0.655
3rzb 02ZCyclin-dependent kinase 2 2.7.11.22 0.654
4a4o 664Serine/threonine-protein kinase PLK1 2.7.11.21 0.653
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.651
3qxp X64Cyclin-dependent kinase 2 2.7.11.22 0.651
1oi9 N20Cyclin-dependent kinase 2 2.7.11.22 0.650
4ek8 16KCyclin-dependent kinase 2 2.7.11.22 0.650