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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vdg NDP Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vdg NDPAldose reductase 1.1.1.21 1.473
2bgs NDPAldose reductase 1.1.1.21 1.428
3h7u NAPNADPH-dependent aldo-keto reductase, chloroplastic / 1.178
3q67 NAPAldose reductase 1.1.1.21 1.146
2j8t NAPAldose reductase 1.1.1.21 1.132
3v36 NAPAldose reductase 1.1.1.21 1.129
2pf8 NDPAldose reductase 1.1.1.21 1.126
2pev NDPAldose reductase 1.1.1.21 1.111
1x96 NAPAldose reductase 1.1.1.21 1.110
3h7r NAPAldo-keto reductase family 4 member C8 / 1.110
2acq NAPAldose reductase 1.1.1.21 1.102
3dop NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.096
1x98 NAPAldose reductase 1.1.1.21 1.083
1z8a NAPAldose reductase 1.1.1.21 1.083
2iq0 NAPAldose reductase 1.1.1.21 1.083
2acs NAPAldose reductase 1.1.1.21 1.080
2pfh NDPAldose reductase 1.1.1.21 1.076
2acu NAPAldose reductase 1.1.1.21 1.074
1ads NAPAldose reductase 1.1.1.21 1.069
1ah4 NAPAldose reductase 1.1.1.21 1.069
3g1r NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.056
3q65 NAPAldose reductase 1.1.1.21 1.054
4xo7 NAPAldo-keto reductase family 1 member C2 / 1.054
5c7h NDPPutative oxidoreductase / 1.052
1q5m NDPProstaglandin-E(2) 9-reductase 1.1.1.189 1.050
4l1x NAPAldo-keto reductase family 1 member C2 / 1.033
1hqt NAPAlcohol dehydrogenase [NADP(+)] 1.1.1.2 1.024
1k8c NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 1.024
3wcz NAPAldo-keto reductase AKR2E4 / 1.016
3o3r NAPAldose reductase-related protein 1 1.1.1.21 1.011
4jtq NAPAldo-keto reductase family 1 member C2 / 1.006
4g5d NDPProstaglandin F synthase 1.1.1.188 1.005
4jq3 NAPAldo-keto reductase family 1 member C2 / 1.005
3bv7 NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.984
4pmj NAPPutative oxidoreductase / 0.984
3qkz NAPAldose reductase-related protein 1 1.1.1.21 0.983
1ef3 NAPAldose reductase 1.1.1.21 0.972
1az2 NAPAldose reductase 1.1.1.21 0.952
1s1p NAPAldo-keto reductase family 1 member C3 / 0.936
1s1r NAPAldo-keto reductase family 1 member C3 / 0.936
3uzw NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.935
4dz5 NAPAldo-keto reductase family 1 member C3 / 0.933
4ijr NDPD-arabinose dehydrogenase [NAD(P)+] heavy chain 1.1.1.117 0.928
2fvl NAPAldo-keto reductase family 1 member C4 1.1.1.225 0.921
1vp5 NAPOxidoreductase, aldo/keto reductase family / 0.897
3buv NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.897
1c9w NAPAldose reductase-related protein 2 / 0.895
1r38 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.883
4xzn NAPAldo-keto reductase family 1 member B10 1.1.1 0.876
2hdj NDPAldo-keto reductase family 1 member C2 / 0.875
1a80 NDP2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.872
3caq NDP3-oxo-5-beta-steroid 4-dehydrogenase / 0.853
1sm9 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.826
3wbw NDPPutative 2,5-diketo-D-gluconic acid reductase / 0.794
4xzm NAPAldo-keto reductase family 1 member B10 1.1.1 0.782
3ln3 NADAldo-keto reductase family 1 member C13 / 0.781
1ye6 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.776
1ye4 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.766
2hej NDPAldo-keto reductase family 1 member C21 1.1.1 0.762
2clp NDPAflatoxin B1 aldehyde reductase member 3 / 0.743
1z9a NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.742
1mi3 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.729
1gve NAPAflatoxin B1 aldehyde reductase member 3 1 0.725
2he5 NDPAldo-keto reductase family 1 member C21 1.1.1 0.706
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.690
1m9h NAD2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.689
1lqa NDPProtein tas / 0.686
2p5n NDPAldo-keto reductase family 1 member C21 1.1.1 0.686
3lut NAPVoltage-gated potassium channel subunit beta-2 / 0.677
1pz0 NAPProtein IolS 1.1.1 0.669
3v0t ATRPerakine reductase 1.1.1.317 0.667
2r9r NAPVoltage-gated potassium channel subunit beta-2 / 0.663