Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pfh NDP Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pfh NDPAldose reductase 1.1.1.21 1.639
2pev NDPAldose reductase 1.1.1.21 1.461
2pf8 NDPAldose reductase 1.1.1.21 1.443
1x98 NAPAldose reductase 1.1.1.21 1.403
3q67 NAPAldose reductase 1.1.1.21 1.398
2acs NAPAldose reductase 1.1.1.21 1.359
1z8a NAPAldose reductase 1.1.1.21 1.350
2acu NAPAldose reductase 1.1.1.21 1.332
1ads NAPAldose reductase 1.1.1.21 1.331
3v36 NAPAldose reductase 1.1.1.21 1.325
1x96 NAPAldose reductase 1.1.1.21 1.320
2j8t NAPAldose reductase 1.1.1.21 1.312
2iq0 NAPAldose reductase 1.1.1.21 1.291
2acq NAPAldose reductase 1.1.1.21 1.271
3q65 NAPAldose reductase 1.1.1.21 1.204
3h7u NAPNADPH-dependent aldo-keto reductase, chloroplastic / 1.187
2bgs NDPAldose reductase 1.1.1.21 1.130
4pmj NAPPutative oxidoreductase / 1.116
3o3r NAPAldose reductase-related protein 1 1.1.1.21 1.100
5c7h NDPPutative oxidoreductase / 1.086
2vdg NDPAldose reductase 1.1.1.21 1.076
3bv7 NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.048
1ah4 NAPAldose reductase 1.1.1.21 1.027
3h7r NAPAldo-keto reductase family 4 member C8 / 1.019
3qkz NAPAldose reductase-related protein 1 1.1.1.21 1.011
1q5m NDPProstaglandin-E(2) 9-reductase 1.1.1.189 0.979
1ef3 NAPAldose reductase 1.1.1.21 0.966
4g5d NDPProstaglandin F synthase 1.1.1.188 0.962
1a80 NDP2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.952
4ijr NDPD-arabinose dehydrogenase [NAD(P)+] heavy chain 1.1.1.117 0.943
1az2 NAPAldose reductase 1.1.1.21 0.927
3uzw NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.897
3caq NDP3-oxo-5-beta-steroid 4-dehydrogenase / 0.893
3buv NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.892
3wcz NAPAldo-keto reductase AKR2E4 / 0.890
1r38 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.885
1vp5 NAPOxidoreductase, aldo/keto reductase family / 0.881
4jtq NAPAldo-keto reductase family 1 member C2 / 0.876
3g1r NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.872
1s1p NAPAldo-keto reductase family 1 member C3 / 0.870
1k8c NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.865
3dop NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.859
4xo7 NAPAldo-keto reductase family 1 member C2 / 0.854
3wbw NDPPutative 2,5-diketo-D-gluconic acid reductase / 0.847
4jq3 NAPAldo-keto reductase family 1 member C2 / 0.846
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.834
4dz5 NAPAldo-keto reductase family 1 member C3 / 0.832
1zgd NAPChalcone reductase / 0.826
2fvl NAPAldo-keto reductase family 1 member C4 1.1.1.225 0.826
4l1x NAPAldo-keto reductase family 1 member C2 / 0.824
1mi3 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.817
2hdj NDPAldo-keto reductase family 1 member C2 / 0.812
1ye4 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.808
1s1r NAPAldo-keto reductase family 1 member C3 / 0.799
4xzn NAPAldo-keto reductase family 1 member B10 1.1.1 0.797
1sm9 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.795
4xzm NAPAldo-keto reductase family 1 member B10 1.1.1 0.788
1m9h NAD2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.784
1ye6 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.769
3ln3 NADAldo-keto reductase family 1 member C13 / 0.754
2he5 NDPAldo-keto reductase family 1 member C21 1.1.1 0.747
1hqt NAPAlcohol dehydrogenase [NADP(+)] 1.1.1.2 0.742
2hej NDPAldo-keto reductase family 1 member C21 1.1.1 0.742
2clp NDPAflatoxin B1 aldehyde reductase member 3 / 0.723
1c9w NAPAldose reductase-related protein 2 / 0.717
1og6 NAPOxidoreductase YdhF 1 0.710
2bp1 NDPAflatoxin B1 aldehyde reductase member 2 / 0.706
1gve NAPAflatoxin B1 aldehyde reductase member 3 1 0.703
1z9a NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.703
2p5n NDPAldo-keto reductase family 1 member C21 1.1.1 0.701
1lwi NAP3-alpha-hydroxysteroid dehydrogenase 1.1.1.50 0.691
1lqa NDPProtein tas / 0.688
4h8n NDPNADPH-dependent conjugated polyketone reductase C2 / 0.677
1qrq NDPVoltage-gated potassium channel subunit beta-2 / 0.662
1pz0 NAPProtein IolS 1.1.1 0.660