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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2opn SUF Farnesyl pyrophosphate synthase 2.5.1.10

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2opn SUFFarnesyl pyrophosphate synthase 2.5.1.10 0.833
2uze C95Cyclin-dependent kinase 2 2.7.11.22 0.671
4blt APCNTPase P4 / 0.669
4mfe BTNPyruvate carboxylase / 0.666
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.665
1mo8 ATPSodium/potassium-transporting ATPase subunit alpha-1 3.6.3.9 0.663
3odk ODKPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1 5.2.1.8 0.663
2pws IBPBasic phospholipase A2 VRV-PL-VIIIa 3.1.1.4 0.661
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.658
2vtl LZ5Cyclin-dependent kinase 2 2.7.11.22 0.657
4guk P2GNeuronal calcium sensor 1 / 0.657
1hwl ADP3-hydroxy-3-methylglutaryl-coenzyme A reductase 1.1.1.34 0.656
3m50 EBT14-3-3-like protein C / 0.656
3m50 EBTPlasma membrane ATPase / 0.656
1m9k 7NINitric oxide synthase, endothelial 1.14.13.39 0.654
2gyw OBIAcetylcholinesterase 3.1.1.7 0.654
2yeg XQGHeat shock protein HSP 90-alpha / 0.654
4diq PD2Ribosomal oxygenase 1 / 0.653
5cwa 0GAAnthranilate synthase component 1 4.1.3.27 0.653
2g7m AN0Ornithine carbamoyltransferase / 0.652
3keg MREFMN-dependent NADH-azoreductase 1 / 0.652
3kzo AN0N-acetylornithine carbamoyltransferase 2.1.3.9 0.652
3veh 0GASalicylate synthase / 0.652