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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ntv P1H Enoyl-[acyl-carrier-protein] reductase [NADH]

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ntv P1HEnoyl-[acyl-carrier-protein] reductase [NADH] / 1.195
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.966
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.946
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.911
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.902
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.897
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.894
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.889
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.885
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.880
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.879
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.876
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.858
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.855
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.849
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.845
4dti NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.843
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.841
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.831
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.830
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.823
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.816
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.801
5koi NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.797
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.795
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.793
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.787
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.776
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.776
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.766
4bgi NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.760
2pr2 DG1Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.739
3o03 NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) / 0.730
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.716
3s55 NADPutative short-chain dehydrogenase/reductase / 0.715
3sx2 NADUncharacterized protein / 0.713
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.712
4qxm NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.712
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.708
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.708
3r3s NADPutative oxidoreductase / 0.704
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.703
2yut NAPPutative short-chain oxidoreductase / 0.701
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.700
3icp NADNAD-dependent epimerase/dehydratase / 0.700
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.700
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.696
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.694
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.693
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.692
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.692
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.690
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.689
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.688
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.686
4hwk NAPSepiapterin reductase 1.1.1.153 0.686
4qed NAPElxO / 0.686
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.686
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.685
3ak4 NADNADH-dependent quinuclidinone reductase / 0.684
3d3w NAPL-xylulose reductase 1.1.1.10 0.684
3sju NDPKeto reductase / 0.684
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.684
2wsb NADGalactitol dehydrogenase / 0.683
1pr9 NAPL-xylulose reductase 1.1.1.10 0.682
1x7g NAPPutative ketoacyl reductase 1.3.1 0.682
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.681
1oaa NAPSepiapterin reductase 1.1.1.153 0.681
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.681
2b36 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.680
5jyd NADShort chain dehydrogenase / 0.680
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.679
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.679
4b79 NADProbable short-chain dehydrogenase / 0.679
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.679
2p5y NADUDP-glucose 4-epimerase / 0.678
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.678
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.678
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.678
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.677
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.676
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.675
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.674
3wds NADNADH-dependent quinuclidinone reductase / 0.674
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.674
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.673
4fn4 NADShort chain dehydrogenase / 0.673
3o26 NDPSalutaridine reductase / 0.671
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.670
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.669
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.669
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.669
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.669
4yag NAIC alpha-dehydrogenase / 0.669
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.668
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.668
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.667
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.667
3qrw NDPPutative ketoacyl reductase 1.3.1 0.667
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.666
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.666
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.664
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.663
1iy8 NADLevodione reductase / 0.663
1x7h NDPPutative ketoacyl reductase 1.3.1 0.663
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.663
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.663
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.663
4hxy NDPPlm1 / 0.663
5d2e NAPMlnE / 0.663
1sby NADAlcohol dehydrogenase 1.1.1.1 0.662
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.661
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.661
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.660
4o1m NADEnoyl-acyl carrier reductase / 0.660
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.659
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.659
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.659
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.658
3tsc NADUncharacterized protein / 0.658
2b69 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.656
2dte NAIGlucose 1-dehydrogenase related protein / 0.656
4dbz NDPPutative ketoacyl reductase 1.3.1 0.655
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.654
1w4z NAPPutative ketoacyl reductase 1.3.1 0.654
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.654
1ipe NDPTropinone reductase 2 1.1.1.236 0.653
5jla NADPutative short-chain dehydrogenase/reductase / 0.653
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.652
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.652
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.652
1b15 NAEAlcohol dehydrogenase 1.1.1.1 0.650
3ko8 NADNAD-dependent epimerase/dehydratase / 0.650