Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ldb NAD L-lactate dehydrogenase 1.1.1.27

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.984
1uxj NADMalate dehydrogenase / 0.733
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.732
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.726
4c4o NADSADH / 0.713
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.713
2voj NADAlanine dehydrogenase 1.4.1.1 0.712
4j49 NADUncharacterized protein / 0.710
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.708
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.707
3wsw NADL-lactate dehydrogenase / 0.701
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.700
4j43 NADUncharacterized protein / 0.699
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.698
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.697
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.696
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.696
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.696
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.696
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.696
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.696
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.695
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.695
1o6z NADMalate dehydrogenase / 0.692
2x0i NAIMalate dehydrogenase / 0.692
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.692
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.691
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.690
3adp NAILambda-crystallin 1.1.1.45 0.690
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.689
4gl4 NAIAlcohol dehydrogenase class-3 / 0.687
4oaq NDPR-specific carbonyl reductase / 0.684
1c1d NAIPhenylalanine dehydrogenase / 0.683
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.683
1gv0 NADMalate dehydrogenase / 0.682
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.682
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.681
1xcb NADRedox-sensing transcriptional repressor Rex / 0.681
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.681
4lcj NADC-terminal-binding protein 2 / 0.681
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.680
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.680
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.680
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.680
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.679
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.679
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.679
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.677
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.676
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.675
1sow NADL-lactate dehydrogenase 1.1.1.27 0.674
2vhx NADAlanine dehydrogenase 1.4.1.1 0.673
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.671
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.671
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.671
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.671
3nt2 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.671
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.670
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.670
1uxk NADMalate dehydrogenase / 0.668
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.668
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.665
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.665
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.664
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.664
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.663
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.663
1u8x NADMaltose-6'-phosphate glucosidase 3.2.1.122 0.662
1ur5 NADMalate dehydrogenase / 0.662
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.662
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.661
1yqd NAPSinapyl alcohol dehydrogenase / 0.660
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.660
1ib6 NADMalate dehydrogenase / 0.659
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.659
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.659
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.658
1pzh NADLactate dehydrogenase / 0.658
4j4b NAIUncharacterized protein / 0.658
2dfv NADL-threonine 3-dehydrogenase / 0.657
1guy NADMalate dehydrogenase / 0.656
1ywg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
2g5c NADPrephenate dehydrogenase / 0.655
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.655
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.654
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.654
4cpd NADAlcohol dehydrogenase / 0.654
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.653
1llu NADAlcohol dehydrogenase / 0.653
1pjc NADAlanine dehydrogenase / 0.653
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.653
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.653
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.653
2o4c NADErythronate-4-phosphate dehydrogenase / 0.653
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.653
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.653
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.652
1ie3 NADMalate dehydrogenase / 0.652
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.652
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.652
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.651
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.651
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.650