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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2gnh H52 cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2gnh H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.858
2gnl H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.791
1q8u H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.759
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4e5l DBHPolymerase acidic protein / 0.744
2f2u M77Rho-associated protein kinase 2 2.7.11.1 0.730
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
1q8w M77cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.680
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ydt IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.656
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.654
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.654
2vth LZ2Cyclin-dependent kinase 2 2.7.11.22 0.653
2f7x 4EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.650