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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2euh NAP NADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 1.370
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 1.075
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.946
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.944
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.940
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.939
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.931
3b4w NADAldehyde dehydrogenase family protein / 0.931
2jg7 NADAntiquitin / 0.930
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.930
4i8q NADPutative betaine aldehyde dehyrogenase / 0.923
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.917
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.911
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.903
4pz2 NADAldehyde dehydrogenase 2-6 / 0.901
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.898
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.891
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.889
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.879
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.877
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.865
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.865
4i8p NADAminoaldehyde dehydrogenase 1 / 0.863
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.852
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.852
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.847
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.847
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.844
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.844
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.843
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.840
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.839
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.814
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.814
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.810
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.804
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.801
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.800
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.794
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.785
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.778
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.766
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.759
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.758
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.758
3haz NADBifunctional protein PutA / 0.756
4i3v NADAldehyde dehydrogenase (NAD+) / 0.748
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.744
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.744
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.734
4i3w NADAldehyde dehydrogenase (NAD+) / 0.730
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.725
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.716
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.715
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.697
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.695
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.694
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.694
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.693
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.690
4f3x NADPutative aldehyde dehydrogenase / 0.690
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.687
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.687
2esd NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.687
4nmk NAPAldehyde dehydrogenase / 0.687
4h73 NDPAldehyde dehydrogenase / 0.681
4nmj NAPAldehyde dehydrogenase / 0.679
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.670
3iwj NADAminoaldehyde dehydrogenase / 0.669
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.668
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.667
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.666
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.659
4c3s NADAldehyde Dehydrogenase / 0.658