Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b7a IZA Tyrosine-protein kinase JAK2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2b7a IZATyrosine-protein kinase JAK2 / 0.970
3eyh IZATyrosine-protein kinase JAK1 / 0.927
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4k77 1Q4Tyrosine-protein kinase JAK1 / 0.714
4ft7 H3KSerine/threonine-protein kinase Chk1 2.7.11.1 0.689
3lxp IZANon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.683
4ft5 H2KSerine/threonine-protein kinase Chk1 2.7.11.1 0.681
4ft3 H1KSerine/threonine-protein kinase Chk1 2.7.11.1 0.679
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.673
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.670
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.663
3lxk MI1Tyrosine-protein kinase JAK3 2.7.10.2 0.661
4e5f 0N7Polymerase acidic protein / 0.660
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.659
3r7v Z02Cyclin-dependent kinase 2 2.7.11.22 0.653
3c7q XINVascular endothelial growth factor receptor 2 2.7.10.1 0.652
3qx2 X63Cyclin-dependent kinase 2 2.7.11.22 0.652
5ax3 5IDMitogen-activated protein kinase 1 2.7.11.24 0.652
1xjd STUProtein kinase C theta type 2.7.11.13 0.651
3rpo 24ZCyclin-dependent kinase 2 2.7.11.22 0.651
3rvg 17PTyrosine-protein kinase JAK2 / 0.650