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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2a92 NAI L-lactate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2a92 NAIL-lactate dehydrogenase / 1.005
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.960
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.953
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.901
1pzh NADLactate dehydrogenase / 0.881
2aa3 AP0L-lactate dehydrogenase / 0.874
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.863
1pzf A3DLactate dehydrogenase / 0.862
1sow NADL-lactate dehydrogenase 1.1.1.27 0.853
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.844
1pzg A3DLactate dehydrogenase / 0.843
4ros APRMalate dehydrogenase / 0.816
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.806
1bdm NAXMalate dehydrogenase / 0.796
5a1t NAIL-lactate dehydrogenase / 0.794
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.792
1gv0 NADMalate dehydrogenase / 0.781
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.769
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.758
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.752
1uxk NADMalate dehydrogenase / 0.748
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.748
4i1i NADMalate dehydrogenase / 0.745
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.744
1bmd NADMalate dehydrogenase / 0.739
1o6z NADMalate dehydrogenase / 0.737
1ib6 NADMalate dehydrogenase / 0.736
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.733
2x0i NAIMalate dehydrogenase / 0.732
3gvh NADMalate dehydrogenase / 0.732
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.729
1wze NADMalate dehydrogenase / 0.727
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.725
1b8v NADMalate dehydrogenase / 0.724
1f8f NADBenzyl alcohol dehydrogenase / 0.723
1uxj NADMalate dehydrogenase / 0.720
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.718
4wlo NAIMalate dehydrogenase, mitochondrial 1.1.1.37 0.718
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.717
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.717
1wzi NDPMalate dehydrogenase / 0.715
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.713
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.712
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.712
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.711
1x7d NADPutative ornithine cyclodeaminase / 0.710
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.707
2hjr APRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase / 0.706
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.706
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.705
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.701
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.697
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.697
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.694
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.694
1y7t NDPMalate dehydrogenase / 0.694
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.693
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.693
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.691
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.691
2dvm NAD439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme] / 0.689
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.688
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.686
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.685
1b8u NADMalate dehydrogenase / 0.684
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.684
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.684
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.683
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.683
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.682
4j43 NADUncharacterized protein / 0.682
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.681
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.680
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.680
1u7h NADPutative ornithine cyclodeaminase / 0.680
3kb6 NADD-lactate dehydrogenase / 0.675
4cpd NADAlcohol dehydrogenase / 0.675
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.673
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.672
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.671
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.670
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.669
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.669
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.669
1ie3 NADMalate dehydrogenase / 0.668
2d8a NADL-threonine 3-dehydrogenase / 0.668
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.668
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.667
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.666
4j49 NADUncharacterized protein / 0.666
4weq NAPNAD-dependent dehydrogenase / 0.666
1c1d NAIPhenylalanine dehydrogenase / 0.665
1emd NADMalate dehydrogenase / 0.665
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.665
3oet NADErythronate-4-phosphate dehydrogenase / 0.665
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.665
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.664
3m2t NADProbable dehydrogenase / 0.664
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.662
4jk3 NADUncharacterized protein / 0.662
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.661
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.661
1p1i NADInositol-3-phosphate synthase 5.5.1.4 0.660
4j4b NAIUncharacterized protein / 0.660
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.659
4gl4 NAIAlcohol dehydrogenase class-3 / 0.658
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.657
2ome NADC-terminal-binding protein 2 / 0.657
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.657
2dc1 NADProbable L-aspartate dehydrogenase / 0.656
3qvt NAIMyo-inositol-1-phosphate synthase (Ino1) / 0.656
3gvi ADPMalate dehydrogenase / 0.655
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.655
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.655
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.654
1hku NADC-terminal-binding protein 1 1.1.1 0.653
4ki0 ANPMaltose/maltodextrin import ATP-binding protein MalK / 0.653
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.652
4oaq NDPR-specific carbonyl reductase / 0.652
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.651
2hu2 NADC-terminal binding protein 1 / 0.651
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.650
1nbo NADGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.650
1yqd NAPSinapyl alcohol dehydrogenase / 0.650
2g5c NADPrephenate dehydrogenase / 0.650
2o4c NADErythronate-4-phosphate dehydrogenase / 0.650
3k2b NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.650