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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1zxn ADP DNA topoisomerase 2-alpha 5.99.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1zxn ADPDNA topoisomerase 2-alpha 5.99.1.3 1.071
4r1f ADPDNA topoisomerase 2-alpha 5.99.1.3 0.876
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 0.829
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.749
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.730
3a0t ADPSensor histidine kinase / 0.725
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.719
4prv ADPDNA gyrase subunit B / 0.706
1z5a ADPType 2 DNA topoisomerase 6 subunit B / 0.696
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.692
4prx ADPDNA gyrase subunit B / 0.688
3sl2 ATPSensor histidine kinase WalK / 0.686
2xcm ADPCytosolic heat shock protein 90 / 0.683
2ior ADPChaperone protein HtpG / 0.682
4xcl AGSHeat shock cognate 90 kDa protein / 0.672
4r3a ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.661
4gqt ADPHeat shock protein 90 / 0.660
1q3s ADPThermosome subunit alpha / 0.658
4ivg ANPTNF receptor-associated protein 1 / 0.655
4xc0 ACPHeat shock cognate 90 kDa protein / 0.655
1ei1 ANPDNA gyrase subunit B / 0.654
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.654
2bu2 ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.652
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.652
2bu8 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.651
1s16 ANPDNA topoisomerase 4 subunit B / 0.650
3gie ACPSensor histidine kinase DesK 2.7.13.3 0.650