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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z8a NAP Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1z8a NAPAldose reductase 1.1.1.21 1.575
2j8t NAPAldose reductase 1.1.1.21 1.573
2pev NDPAldose reductase 1.1.1.21 1.572
2pf8 NDPAldose reductase 1.1.1.21 1.572
1x98 NAPAldose reductase 1.1.1.21 1.554
3q67 NAPAldose reductase 1.1.1.21 1.532
1x96 NAPAldose reductase 1.1.1.21 1.530
2acq NAPAldose reductase 1.1.1.21 1.511
2iq0 NAPAldose reductase 1.1.1.21 1.508
1ads NAPAldose reductase 1.1.1.21 1.484
3v36 NAPAldose reductase 1.1.1.21 1.470
2acs NAPAldose reductase 1.1.1.21 1.461
2acu NAPAldose reductase 1.1.1.21 1.456
3q65 NAPAldose reductase 1.1.1.21 1.366
3h7u NAPNADPH-dependent aldo-keto reductase, chloroplastic / 1.357
2pfh NDPAldose reductase 1.1.1.21 1.350
2bgs NDPAldose reductase 1.1.1.21 1.304
1ah4 NAPAldose reductase 1.1.1.21 1.291
3qkz NAPAldose reductase-related protein 1 1.1.1.21 1.262
4pmj NAPPutative oxidoreductase / 1.250
1ef3 NAPAldose reductase 1.1.1.21 1.247
5c7h NDPPutative oxidoreductase / 1.215
3bv7 NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.192
4g5d NDPProstaglandin F synthase 1.1.1.188 1.191
3h7r NAPAldo-keto reductase family 4 member C8 / 1.140
4xzn NAPAldo-keto reductase family 1 member B10 1.1.1 1.136
1az2 NAPAldose reductase 1.1.1.21 1.114
3uzw NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.113
3o3r NAPAldose reductase-related protein 1 1.1.1.21 1.109
4ijr NDPD-arabinose dehydrogenase [NAD(P)+] heavy chain 1.1.1.117 1.091
2vdg NDPAldose reductase 1.1.1.21 1.083
1q5m NDPProstaglandin-E(2) 9-reductase 1.1.1.189 1.078
3g1r NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.051
4xzm NAPAldo-keto reductase family 1 member B10 1.1.1 1.043
3buv NAP3-oxo-5-beta-steroid 4-dehydrogenase / 1.023
1hqt NAPAlcohol dehydrogenase [NADP(+)] 1.1.1.2 1.018
3wcz NAPAldo-keto reductase AKR2E4 / 1.013
1k8c NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 1.012
3dop NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.986
3wbw NDPPutative 2,5-diketo-D-gluconic acid reductase / 0.971
1vp5 NAPOxidoreductase, aldo/keto reductase family / 0.957
1s1r NAPAldo-keto reductase family 1 member C3 / 0.950
4jtq NAPAldo-keto reductase family 1 member C2 / 0.948
1a80 NDP2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.938
3caq NDP3-oxo-5-beta-steroid 4-dehydrogenase / 0.933
2fvl NAPAldo-keto reductase family 1 member C4 1.1.1.225 0.930
1mi3 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.925
1r38 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.905
2hdj NDPAldo-keto reductase family 1 member C2 / 0.902
1c9w NAPAldose reductase-related protein 2 / 0.900
1zgd NAPChalcone reductase / 0.896
4xo7 NAPAldo-keto reductase family 1 member C2 / 0.893
4dz5 NAPAldo-keto reductase family 1 member C3 / 0.890
4l1x NAPAldo-keto reductase family 1 member C2 / 0.868
1s1p NAPAldo-keto reductase family 1 member C3 / 0.859
1m9h NAD2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.857
4jq3 NAPAldo-keto reductase family 1 member C2 / 0.840
1ye4 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.837
1sm9 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.800
3ln3 NADAldo-keto reductase family 1 member C13 / 0.787
1ye6 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.786
2hej NDPAldo-keto reductase family 1 member C21 1.1.1 0.772
1z9a NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.748
1lwi NAP3-alpha-hydroxysteroid dehydrogenase 1.1.1.50 0.723
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.713
1og6 NAPOxidoreductase YdhF 1 0.711
2he5 NDPAldo-keto reductase family 1 member C21 1.1.1 0.711
2bp1 NDPAflatoxin B1 aldehyde reductase member 2 / 0.708
4h8n NDPNADPH-dependent conjugated polyketone reductase C2 / 0.689
3wg6 NDPNADPH-dependent conjugated polyketone reductase C1 / 0.688
2clp NDPAflatoxin B1 aldehyde reductase member 3 / 0.681
4aub NAPL-glyceraldehyde 3-phosphate reductase 1.1.1 0.665
1gve NAPAflatoxin B1 aldehyde reductase member 3 1 0.660
1qrq NDPVoltage-gated potassium channel subunit beta-2 / 0.656
3lnm NAPVoltage-gated potassium channel subunit beta-2 / 0.650