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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1t41 ID5 Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1t41 ID5Aldose reductase 1.1.1.21 1.269
1z3n 3NAAldose reductase 1.1.1.21 0.861
3g5e Q74Aldose reductase 1.1.1.21 0.813
3m4h 388Aldose reductase 1.1.1.21 0.788
1t40 ID5Aldose reductase 1.1.1.21 0.759
3len ZSTAldose reductase 1.1.1.21 0.752
2pdx ZSTAldose reductase 1.1.1.21 0.723
2dux ZSTAldose reductase 1.1.1.21 0.719
2pdm ZSTAldose reductase 1.1.1.21 0.719
2pdi ZSTAldose reductase 1.1.1.21 0.713
4gca 2X9Aldose reductase 1.1.1.21 0.713
2pdq 47DAldose reductase 1.1.1.21 0.701
2pdf ZSTAldose reductase 1.1.1.21 0.700
2fz9 ZSTAldose reductase 1.1.1.21 0.691
3m64 393Aldose reductase 1.1.1.21 0.691
2pdj 393Aldose reductase 1.1.1.21 0.687
2pzn 393Aldose reductase 1.1.1.21 0.677
3m0i ZSTAldose reductase 1.1.1.21 0.675
2dv0 ZSTAldose reductase 1.1.1.21 0.674
2ikj 393Aldose reductase 1.1.1.21 0.672
3ghu LDTAldose reductase 1.1.1.21 0.672
3t42 3T4Aldose reductase 1.1.1.21 0.671
2pdc 393Aldose reductase 1.1.1.21 0.666
2fz8 ZSTAldose reductase 1.1.1.21 0.663
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2iki 388Aldose reductase 1.1.1.21 0.660
4e5i 0N9Polymerase acidic protein / 0.660
4e5l DBHPolymerase acidic protein / 0.660
2pdn 47DAldose reductase 1.1.1.21 0.658
2hv5 ZSTAldose reductase 1.1.1.21 0.656
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.655
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.655
4e5f 0N7Polymerase acidic protein / 0.655
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.655
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.654
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.653
3ght LDTAldose reductase 1.1.1.21 0.652
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.651