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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1sow NAD L-lactate dehydrogenase 1.1.1.27

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1sow NADL-lactate dehydrogenase 1.1.1.27 1.115
1pzh NADLactate dehydrogenase / 1.068
1t2d NADL-lactate dehydrogenase 1.1.1.27 1.057
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 1.001
2a94 AP0L-lactate dehydrogenase 1.1.1.27 1.000
1pzg A3DLactate dehydrogenase / 0.999
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.971
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.961
1pzf A3DLactate dehydrogenase / 0.931
2aa3 AP0L-lactate dehydrogenase / 0.906
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.902
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.878
1b8v NADMalate dehydrogenase / 0.853
2a92 NAIL-lactate dehydrogenase / 0.853
4ros APRMalate dehydrogenase / 0.853
1gv0 NADMalate dehydrogenase / 0.845
1u7h NADPutative ornithine cyclodeaminase / 0.830
2x0i NAIMalate dehydrogenase / 0.828
1x7d NADPutative ornithine cyclodeaminase / 0.823
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.820
1wze NADMalate dehydrogenase / 0.816
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.815
1uxk NADMalate dehydrogenase / 0.809
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.809
5a1t NAIL-lactate dehydrogenase / 0.788
4i1i NADMalate dehydrogenase / 0.786
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.784
1bmd NADMalate dehydrogenase / 0.778
1bdm NAXMalate dehydrogenase / 0.777
4j49 NADUncharacterized protein / 0.777
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.777
4j43 NADUncharacterized protein / 0.770
4jk3 NADUncharacterized protein / 0.767
1ib6 NADMalate dehydrogenase / 0.764
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.763
1b8u NADMalate dehydrogenase / 0.761
1uxj NADMalate dehydrogenase / 0.756
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.752
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.749
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.748
1ie3 NADMalate dehydrogenase / 0.746
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.745
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.745
1wzi NDPMalate dehydrogenase / 0.743
3gvh NADMalate dehydrogenase / 0.742
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.742
4c4o NADSADH / 0.741
3oet NADErythronate-4-phosphate dehydrogenase / 0.738
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.734
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.729
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.729
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.728
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.727
3two NDPMannitol dehydrogenase / 0.727
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.726
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.726
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.724
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.723
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.722
4j49 NAIUncharacterized protein / 0.722
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.721
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.721
2hjr APRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase / 0.720
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.719
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.714
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.714
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.714
1y7t NDPMalate dehydrogenase / 0.712
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.712
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.711
3jv7 NADSecondary alcohol dehydrogenase / 0.709
2nad NADFormate dehydrogenase / 0.708
2gsd NADFormate dehydrogenase / 0.707
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.706
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.706
4j4b NAIUncharacterized protein / 0.706
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.706
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.704
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.702
1o6z NADMalate dehydrogenase / 0.702
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.702
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.702
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.702
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.701
2dc1 NADProbable L-aspartate dehydrogenase / 0.701
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.700
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.700
2vhx NADAlanine dehydrogenase 1.4.1.1 0.697
4oaq NDPR-specific carbonyl reductase / 0.696
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.695
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.694
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.692
1f8f NADBenzyl alcohol dehydrogenase / 0.690
1hku NADC-terminal-binding protein 1 1.1.1 0.690
2d8a NADL-threonine 3-dehydrogenase / 0.690
4k28 NADShikimate dehydrogenase family protein / 0.690
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.689
2x0r NADMalate dehydrogenase / 0.689
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.689
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.687
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.687
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.686
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.686
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.685
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.685
3wle NAD(R)-specific carbonyl reductase / 0.684
1yqd NAPSinapyl alcohol dehydrogenase / 0.682
4b7x NAPProbable oxidoreductase / 0.682
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.682
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.681
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.680
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.678
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.678
3ggp NADPrephenate dehydrogenase / 0.678
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.678
1yqx NAPSinapyl alcohol dehydrogenase / 0.676
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.676
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.675
4z0p NDPNAD-dependent dehydrogenase / 0.675
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.674
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.674
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.674
4wlo NAIMalate dehydrogenase, mitochondrial 1.1.1.37 0.674
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.673
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.672
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.671
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.671
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.671
2hu2 NADC-terminal binding protein 1 / 0.669
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.668
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.668
3wsw NADL-lactate dehydrogenase / 0.668
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.666
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.666
2y05 NAPProstaglandin reductase 1 / 0.666
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.665
1c1d NAIPhenylalanine dehydrogenase / 0.664
3qvt NAIMyo-inositol-1-phosphate synthase (Ino1) / 0.664
3geg NADShort-chain dehydrogenase/reductase SDR / 0.663
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.662
2xaa NADSecondary alcohol dehydrogenase / 0.661
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.660
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.660
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.660
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.658
3doc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.658
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.658
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.658
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.658
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.658
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.657
1u1i NADMyo-inositol-1-phosphate synthase (Ino1) / 0.657
3anm NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.657
3fvq ATPFe(3+) ions import ATP-binding protein FbpC / 0.657
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.656
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.655
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.655
1pjc NADAlanine dehydrogenase / 0.655
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.655
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.655
3gvi ADPMalate dehydrogenase / 0.655
3uko NADAlcohol dehydrogenase class-3 / 0.655
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.655
2c20 NADUDP-glucose 4-epimerase / 0.654
4cuk NAID-lactate dehydrogenase / 0.654
1llu NADAlcohol dehydrogenase / 0.653
2e37 NADL-lactate dehydrogenase / 0.653
2ejv NADL-threonine 3-dehydrogenase / 0.653
2dfv NADL-threonine 3-dehydrogenase / 0.652
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.652
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.651
4cpd NADAlcohol dehydrogenase / 0.650