Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pzh NAD Lactate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1pzh NADLactate dehydrogenase / 1.119
1t2d NADL-lactate dehydrogenase 1.1.1.27 1.083
1sow NADL-lactate dehydrogenase 1.1.1.27 1.068
1pzg A3DLactate dehydrogenase / 1.023
2a94 AP0L-lactate dehydrogenase 1.1.1.27 1.006
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.999
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.995
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.978
1pzf A3DLactate dehydrogenase / 0.966
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.943
4ros APRMalate dehydrogenase / 0.886
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.885
2a92 NAIL-lactate dehydrogenase / 0.881
1gv0 NADMalate dehydrogenase / 0.879
2aa3 AP0L-lactate dehydrogenase / 0.869
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.848
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.847
5a1t NAIL-lactate dehydrogenase / 0.839
1b8v NADMalate dehydrogenase / 0.832
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.820
1bmd NADMalate dehydrogenase / 0.818
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.818
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.815
1ib6 NADMalate dehydrogenase / 0.813
1uxk NADMalate dehydrogenase / 0.807
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.807
1uxj NADMalate dehydrogenase / 0.805
1u7h NADPutative ornithine cyclodeaminase / 0.802
2x0i NAIMalate dehydrogenase / 0.800
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.796
1x7d NADPutative ornithine cyclodeaminase / 0.794
4i1i NADMalate dehydrogenase / 0.786
1ie3 NADMalate dehydrogenase / 0.784
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.781
1bdm NAXMalate dehydrogenase / 0.780
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.779
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.777
4j43 NADUncharacterized protein / 0.776
1wze NADMalate dehydrogenase / 0.774
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.771
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.771
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.770
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.764
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.763
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.762
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.762
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.760
3gvh NADMalate dehydrogenase / 0.760
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.757
1b8u NADMalate dehydrogenase / 0.752
4jk3 NADUncharacterized protein / 0.752
3two NDPMannitol dehydrogenase / 0.751
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.751
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.750
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.746
2hjr APRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase / 0.744
3jv7 NADSecondary alcohol dehydrogenase / 0.744
1wzi NDPMalate dehydrogenase / 0.742
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.742
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.741
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.741
4j49 NADUncharacterized protein / 0.741
1o6z NADMalate dehydrogenase / 0.738
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.736
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.735
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.734
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.731
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.731
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.728
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.728
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.726
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.724
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.723
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.722
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.722
2dvm NAD439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme] / 0.721
4oaq NDPR-specific carbonyl reductase / 0.721
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.720
4j49 NAIUncharacterized protein / 0.719
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.717
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.716
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.715
2nad NADFormate dehydrogenase / 0.713
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.713
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.712
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.712
4b7x NAPProbable oxidoreductase / 0.712
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.711
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.710
2x0r NADMalate dehydrogenase / 0.710
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.710
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.709
1yqd NAPSinapyl alcohol dehydrogenase / 0.709
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.708
4j4b NAIUncharacterized protein / 0.708
1yqx NAPSinapyl alcohol dehydrogenase / 0.706
2dc1 NADProbable L-aspartate dehydrogenase / 0.705
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.705
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.704
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.704
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.703
3oet NADErythronate-4-phosphate dehydrogenase / 0.701
1f8f NADBenzyl alcohol dehydrogenase / 0.699
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.699
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.698
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.697
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.696
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.696
2xaa NADSecondary alcohol dehydrogenase / 0.694
2yy7 NADL-threonine dehydrogenase / 0.694
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.693
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.693
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.692
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.692
2voj NADAlanine dehydrogenase 1.4.1.1 0.692
3kb6 NADD-lactate dehydrogenase / 0.692
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.691
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.690
1c1d NAIPhenylalanine dehydrogenase / 0.687
2vhx NADAlanine dehydrogenase 1.4.1.1 0.687
4cr8 NADN-acylmannosamine 1-dehydrogenase 1.1.1.233 0.687
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.686
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.684
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.683
2o4c NADErythronate-4-phosphate dehydrogenase / 0.683
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.683
4xq9 NADHomospermidine synthase 2.5.1.44 0.682
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.680
2b5v NAPGlucose 1-dehydrogenase / 0.680
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.679
2y05 NAPProstaglandin reductase 1 / 0.678
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.678
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.677
1llu NADAlcohol dehydrogenase / 0.676
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.676
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.676
1guy NADMalate dehydrogenase / 0.674
2c20 NADUDP-glucose 4-epimerase / 0.674
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.674
4cpd NADAlcohol dehydrogenase / 0.674
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.673
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.673
4l0q NADAlcohol dehydrogenase class-3 / 0.673
4wlo NAIMalate dehydrogenase, mitochondrial 1.1.1.37 0.673
1pjc NADAlanine dehydrogenase / 0.672
3ggp NADPrephenate dehydrogenase / 0.672
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.671
1emd NADMalate dehydrogenase / 0.670
3gvi ADPMalate dehydrogenase / 0.669
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.669
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.668
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.668
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.667
4xrg NADHomospermidine synthase 2.5.1.44 0.667
1omo NADAlanine dehydrogenase / 0.666
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.664
3tqh NDPQuinone oxidoreductase / 0.664
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.663
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.662
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.661
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.660
2yut NAPPutative short-chain oxidoreductase / 0.660
1hku NADC-terminal-binding protein 1 1.1.1 0.659
2d8a NADL-threonine 3-dehydrogenase / 0.659
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.659
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.659
3wmx NADNAD dependent epimerase/dehydratase / 0.659
4cuk NAID-lactate dehydrogenase / 0.659
1g1a NADdTDP-glucose 4,6-dehydratase / 0.658
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.658
3anm NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.658
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.658
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.658
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.658
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.657
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.656
3wfj NAD2-dehydropantoate 2-reductase / 0.656
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.655
2p5y NADUDP-glucose 4-epimerase / 0.655
2e37 NADL-lactate dehydrogenase / 0.654
3fvq ATPFe(3+) ions import ATP-binding protein FbpC / 0.654
5a04 NDPGlucose-fructose oxidoreductase / 0.654
3x2f NAIAdenosylhomocysteinase / 0.653
4ejm NAPPutative zinc-binding dehydrogenase / 0.653
4plp NADHomospermidine synthase 2.5.1.44 0.653
4k28 NADShikimate dehydrogenase family protein / 0.652
4njo NADD-3-phosphoglycerate dehydrogenase, putative / 0.652
1i3l NADUDP-glucose 4-epimerase / 0.651
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.651
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.651
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.651
3nx4 NAPPutative oxidoreductase / 0.651
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.650
1i36 NAPConserved protein / 0.650
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.650
2dph NADFormaldehyde dismutase / 0.650
2pv7 NADT-protein 1.3.1.12 0.650