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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1kqm ANP Myosin heavy chain, striated muscle

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1kqm ANPMyosin heavy chain, striated muscle / 1.073
3tnf GNPRas-related protein Rab-8A / 0.710
2olq ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.709
3law GNPRas-related protein Rab-7a / 0.707
3myk ANPMyosin-2 heavy chain / 0.704
4jsy GTPMetallophosphoesterase / 0.703
4pjj ADPUnconventional myosin-VI / 0.701
2ffq GSPRas-related protein Rab-6B / 0.700
4db1 ANPMyosin-7 / 0.700
1zcb GDPGuanine nucleotide-binding protein subunit alpha-13 / 0.698
2dwp ACP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 2.7.1.105 0.697
4o25 GTPGTP-binding protein Rheb / 0.697
2ic5 GNPRas-related C3 botulinum toxin substrate 3 / 0.696
3onw GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.696
2cls GTPRho-related GTP-binding protein Rho6 / 0.693
3i5x ANPATP-dependent RNA helicase MSS116, mitochondrial 3.6.4.13 0.693
1jx2 ADPMyosin-2 heavy chain / 0.691
3bbp GTPRas-related protein Rab-6A / 0.690
5jlj GNPGTP-binding nuclear protein Ran / 0.690
4qm6 GTPMetallophosphoesterase / 0.689
3tlx ADPAdenylate kinase 2 / 0.688
4ymu ATPABC-type polar amino acid transport system, ATPase component / 0.688
2bku GTPGTP-binding nuclear protein Ran / 0.687
3sqw ANPATP-dependent RNA helicase MSS116, mitochondrial 3.6.4.13 0.687
2w2v GTPRas-related C3 botulinum toxin substrate 2 / 0.684
1s1c GNPTransforming protein RhoA / 0.683
2gil GTPRas-related protein Rab-6A / 0.683
5da9 AGSUncharacterized protein / 0.682
1l2o ADPMyosin heavy chain, striated muscle / 0.681
1zc3 GNPRas-related protein Ral-A / 0.681
2c9o ADPRuvB-like 1 3.6.4.12 0.680
2jj2 ADPATP synthase subunit alpha, mitochondrial / 0.680
2jj2 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.680
3zfd ANPChromosome-associated kinesin KIF4 / 0.680
1tu3 GNPRas-related protein Rab-5A / 0.679
3sqx ANPATP-dependent RNA helicase MSS116, mitochondrial 3.6.4.13 0.678
3tkl GTPRas-related protein Rab-1A / 0.678
1gil GSPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.677
3eg5 GNPCell division control protein 42 homolog / 0.677
3ftq GNPSeptin-2 / 0.677
1mez GDPAdenylosuccinate synthetase isozyme 1 / 0.676
1zc4 GNPRas-related protein Ral-A / 0.676
2v7q ATPATP synthase subunit alpha, mitochondrial / 0.676
2v7q ATPATP synthase subunit beta, mitochondrial 3.6.3.14 0.676
4tlc AGSCircadian clock protein kinase KaiC 2.7.11.1 0.676
1cs4 GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.675
4mkf AP5Adenylate kinase / 0.674
1bmf ANPATP synthase subunit alpha, mitochondrial / 0.673
1bmf ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.673
2q2z ADPKinesin-like protein KIF11 / 0.673
1gia GSPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.672
1a2b GSPTransforming protein RhoA / 0.671
4jky ADPAdenylate kinase / 0.669
2jiz ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.667
3vx4 ATPPutative ABC transporter, ATP-binding protein ComA / 0.667
3zia ATPATP synthase subunit alpha, mitochondrial / 0.667
4uj5 GNPRas-related protein Rab-11A / 0.667
1w0k ADPATP synthase subunit alpha, mitochondrial / 0.666
1w0k ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.666
4dso GSPGTPase KRas / 0.666
1kmq GNPTransforming protein RhoA / 0.665
1z6t ADPApoptotic protease-activating factor 1 / 0.664
2fah GDPPhosphoenolpyruvate carboxykinase [GTP], mitochondrial 4.1.1.32 0.663
4tl9 AGSCircadian clock protein kinase KaiC 2.7.11.1 0.663
1w7i ADPUnconventional myosin-Va / 0.662
3kfl ME8Putative methionyl-tRNA synthetase / 0.662
3n0z 3ATAdenylate cyclase 2 / 0.662
3wt0 ATPCell division protein FtsA / 0.662
2jj1 ADPATP synthase subunit alpha, mitochondrial / 0.661
2jj1 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.661
4pfp ADPUnconventional myosin-VI / 0.661
1azt GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.660
2xau ADPPre-mRNA-splicing factor ATP-dependent RNA helicase PRP43 3.6.4.13 0.660
4cei ANPATP-dependent helicase/deoxyribonuclease subunit B 3.1 0.660
2v7q ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.659
4tl6 ANPCircadian clock protein kinase KaiC 2.7.11.1 0.659
1z2c GNPRho-related GTP-binding protein RhoC / 0.658
1m2o GNPSmall COPII coat GTPase SAR1 3.6.5 0.657
2oap ANPType II secretion system protein (GspE-2) / 0.657
1ny5 ADPTranscriptional regulator (NtrC family) / 0.656
2gks ADPProbable bifunctional SAT/APS kinase 2.7.1.25 0.656
2uz3 TTPThymidine kinase / 0.656
1mmg AGSMyosin-2 heavy chain / 0.655
3bxz ADPProtein translocase subunit SecA / 0.655
4nyj GNPGTPase HRas / 0.654
2db3 ANPATP-dependent RNA helicase vasa, isoform A 3.6.4.13 0.653
3kz1 GSPTransforming protein RhoA / 0.653
4lja ACPChaperone protein ClpB / 0.653
4ko8 AGSTransitional endoplasmic reticulum ATPase 3.6.4.6 0.652
4qnr ATPPsp operon transcriptional activator / 0.652
1h8h ATPATP synthase subunit alpha, mitochondrial / 0.651
1h8h ATPATP synthase subunit beta, mitochondrial 3.6.3.14 0.651
2gvd GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short / 0.651
3kko GNPRas-related protein M-Ras / 0.651
1os1 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.650
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.650
2r9v ATPATP synthase subunit alpha / 0.650
3ruq ADPChaperonin / 0.650