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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1cw3 NAD Aldehyde dehydrogenase, mitochondrial 1.2.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.151
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.884
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.869
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.859
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.814
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.814
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.809
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.805
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.789
4i8p NADAminoaldehyde dehydrogenase 1 / 0.781
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.779
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.774
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.769
3iwj NADAminoaldehyde dehydrogenase / 0.758
4i8q NADPutative betaine aldehyde dehyrogenase / 0.753
4pxl NADAldehyde dehydrogenase3 / 0.749
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.743
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.743
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.735
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.730
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.724
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.724
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.717
3b4w NADAldehyde dehydrogenase family protein / 0.715
5dib NADBetaine-aldehyde dehydrogenase / 0.715
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.713
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.713
5eyu NADBetaine-aldehyde dehydrogenase / 0.707
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.704
4i9b NADPutative betaine aldehyde dehyrogenase / 0.702
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.701
4f3x NADPutative aldehyde dehydrogenase / 0.701
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.699
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.699
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.698
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.697
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.691
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.691
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.688
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.688
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.688
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.687
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.686
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.683
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.681
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.681
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.678
5ez4 NADBetaine-aldehyde dehydrogenase / 0.677
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.674
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.674
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.673
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.671
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.670
1bi9 NADRetinal dehydrogenase 2 / 0.669
2xdr NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.669
4pz2 NADAldehyde dehydrogenase 2-6 / 0.667
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.667
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.664
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.663
2jg7 NADAntiquitin / 0.660
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.657
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.655
4pt3 NDPAldehyde dehydrogenase / 0.655
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.654
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.653
5bt9 NAP3-oxoacyl-(Acyl-carrier-protein) reductase / 0.653