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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1az2 NAP Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1az2 NAPAldose reductase 1.1.1.21 1.411
2iq0 NAPAldose reductase 1.1.1.21 1.220
2acs NAPAldose reductase 1.1.1.21 1.177
2acu NAPAldose reductase 1.1.1.21 1.177
1ads NAPAldose reductase 1.1.1.21 1.152
3q67 NAPAldose reductase 1.1.1.21 1.150
2pf8 NDPAldose reductase 1.1.1.21 1.148
2pev NDPAldose reductase 1.1.1.21 1.141
2acq NAPAldose reductase 1.1.1.21 1.137
3v36 NAPAldose reductase 1.1.1.21 1.137
1x98 NAPAldose reductase 1.1.1.21 1.132
1z8a NAPAldose reductase 1.1.1.21 1.114
2j8t NAPAldose reductase 1.1.1.21 1.101
3o3r NAPAldose reductase-related protein 1 1.1.1.21 1.070
1ef3 NAPAldose reductase 1.1.1.21 1.059
3q65 NAPAldose reductase 1.1.1.21 1.059
3h7u NAPNADPH-dependent aldo-keto reductase, chloroplastic / 1.031
1x96 NAPAldose reductase 1.1.1.21 1.011
1ah4 NAPAldose reductase 1.1.1.21 0.986
4pmj NAPPutative oxidoreductase / 0.954
2vdg NDPAldose reductase 1.1.1.21 0.952
1c9w NAPAldose reductase-related protein 2 / 0.928
2pfh NDPAldose reductase 1.1.1.21 0.927
3dop NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.926
2fvl NAPAldo-keto reductase family 1 member C4 1.1.1.225 0.921
3g1r NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.919
4l1x NAPAldo-keto reductase family 1 member C2 / 0.918
5c7h NDPPutative oxidoreductase / 0.916
1q5m NDPProstaglandin-E(2) 9-reductase 1.1.1.189 0.915
3buv NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.914
4jq3 NAPAldo-keto reductase family 1 member C2 / 0.899
3uzw NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.898
3wcz NAPAldo-keto reductase AKR2E4 / 0.895
4xzn NAPAldo-keto reductase family 1 member B10 1.1.1 0.895
3bv7 NAP3-oxo-5-beta-steroid 4-dehydrogenase / 0.894
3h7r NAPAldo-keto reductase family 4 member C8 / 0.891
3qkz NAPAldose reductase-related protein 1 1.1.1.21 0.883
1hqt NAPAlcohol dehydrogenase [NADP(+)] 1.1.1.2 0.881
2bgs NDPAldose reductase 1.1.1.21 0.881
3caq NDP3-oxo-5-beta-steroid 4-dehydrogenase / 0.872
3wbw NDPPutative 2,5-diketo-D-gluconic acid reductase / 0.866
4xo7 NAPAldo-keto reductase family 1 member C2 / 0.865
4xzm NAPAldo-keto reductase family 1 member B10 1.1.1 0.857
1vp5 NAPOxidoreductase, aldo/keto reductase family / 0.856
4jtq NAPAldo-keto reductase family 1 member C2 / 0.854
4dz5 NAPAldo-keto reductase family 1 member C3 / 0.837
2hdj NDPAldo-keto reductase family 1 member C2 / 0.834
1a80 NDP2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.830
1k8c NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.809
1r38 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.806
1sm9 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.800
1s1p NAPAldo-keto reductase family 1 member C3 / 0.798
4g5d NDPProstaglandin F synthase 1.1.1.188 0.792
4ijr NDPD-arabinose dehydrogenase [NAD(P)+] heavy chain 1.1.1.117 0.776
1ye6 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.746
1s1r NAPAldo-keto reductase family 1 member C3 / 0.743
1mi3 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.732
1zgd NAPChalcone reductase / 0.720
3ln3 NADAldo-keto reductase family 1 member C13 / 0.715
1m9h NAD2,5-diketo-D-gluconic acid reductase A 1.1.1.346 0.696
2clp NDPAflatoxin B1 aldehyde reductase member 3 / 0.694
1z9a NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.671
1ye4 NADNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.665
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.651