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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5cdsNAJAlcohol dehydrogenase E chain1.1.1.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
5cdsNAJAlcohol dehydrogenase E chain1.1.1.11.000
1mgoNADAlcohol dehydrogenase E chain1.1.1.10.678
4nfhNAJAlcohol dehydrogenase E chain1.1.1.10.675
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.658
1a71NADAlcohol dehydrogenase E chain1.1.1.10.643
2jhfNADAlcohol dehydrogenase E chain1.1.1.10.642
4ng5NAJAlcohol dehydrogenase E chain1.1.1.10.618
1axeNADAlcohol dehydrogenase E chain1.1.1.10.612
2oxiNADAlcohol dehydrogenase E chain1.1.1.10.612
4dxhNAJAlcohol dehydrogenase E chain1.1.1.10.611
1adcPADAlcohol dehydrogenase E chain1.1.1.10.610
1axgNADAlcohol dehydrogenase E chain1.1.1.10.602
1adbCNDAlcohol dehydrogenase E chain1.1.1.10.598
1hldNADAlcohol dehydrogenase E chain1.1.1.10.585
1u3vNADAlcohol dehydrogenase 1B1.1.1.10.582
1hszNADAlcohol dehydrogenase 1B1.1.1.10.577
1ht0NADAlcohol dehydrogenase 1C1.1.1.10.566
1agnNADAlcohol dehydrogenase class 4 mu/sigma chain1.1.1.10.559
1ldeNADAlcohol dehydrogenase E chain1.1.1.10.558
4dlbNADS-(hydroxymethyl)glutathione dehydrogenase/0.518
1hdzNADAlcohol dehydrogenase 1B1.1.1.10.504
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.498
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.482
1kolNADGlutathione-independent formaldehyde dehydrogenase/0.475
2fzeAPRAlcohol dehydrogenase class-31.1.1.10.472
1e3lNADAlcohol dehydrogenase 41.1.1.10.470
4jjiNADAlcohol dehydrogenase class-3/0.469
4gl4NAIAlcohol dehydrogenase class-3/0.464
5envNADAlcohol dehydrogenase 11.1.1.10.456
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.451
4w6z8IDAlcohol dehydrogenase 11.1.1.10.449
4wluNADMalate dehydrogenase, mitochondrial1.1.1.370.449
3ukoNADAlcohol dehydrogenase class-3/0.445
1h2bNAJNAD-dependent alcohol dehydrogenase/0.444
2dphNADFormaldehyde dismutase/0.444