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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4wjiNAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4wjiNAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase/1.000
3ggpNADPrephenate dehydrogenase/0.488
1mgoNADAlcohol dehydrogenase E chain1.1.1.10.486
1zh8NAPUncharacterized protein/0.485
3pefNAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase/0.464
4kqwNAPKetol-acid reductoisomerase (NADP(+))/0.463
2jd1NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.460
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.459
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
2g5cNADPrephenate dehydrogenase/0.456
4dplNAPMalonyl-CoA reductase1.2.1.750.456
2oxiNADAlcohol dehydrogenase E chain1.1.1.10.455
1axeNADAlcohol dehydrogenase E chain1.1.1.10.454
2dbrNAPGlyoxylate reductase1.1.1.260.454
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.454
4xyeNADFormate dehydrogenase/0.452
1u3vNADAlcohol dehydrogenase 1B1.1.1.10.451
2gsdNADFormate dehydrogenase/0.450
5cdsNAJAlcohol dehydrogenase E chain1.1.1.10.448
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.446
4jbiNDPAlcohol dehydrogenase (Zinc)/0.446
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.445
4xgiNADGlutamate dehydrogenase/0.445
3ojlNADCap5O/0.443
1a71NADAlcohol dehydrogenase E chain1.1.1.10.440
5hwsNAP2-dehydropantoate 2-reductase/0.440