sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4pah | LNR | Phenylalanine-4-hydroxylase | 1.14.16.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4pah | LNR | Phenylalanine-4-hydroxylase | 1.14.16.1 | 1.000 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.904 | |
| 3pah | XDE | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.760 | |
| 1j8u | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.602 | |
| 1lrm | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.584 | |
| 1tg2 | H2B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.583 | |
| 2toh | HBI | Tyrosine 3-monooxygenase | 1.14.16.2 | 0.571 | |
| 1dmw | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.517 | |
| 3up3 | XCA | aceDAF-12 | / | 0.493 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.480 | |
| 3up0 | D7S | aceDAF-12 | / | 0.478 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.468 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.459 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.456 | |
| 1srf | MTB | Streptavidin | / | 0.454 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.453 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.453 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.452 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2h94 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.451 | |
| 4mrt | COA | 4'-phosphopantetheinyl transferase sfp | 2.7.8 | 0.451 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.449 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.449 | |
| 3gxf | IFM | Glucosylceramidase | 3.2.1.45 | 0.448 | |
| 1ltz | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.447 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.447 | |
| 3ntr | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.447 | |
| 1swt | BTN | Streptavidin | / | 0.446 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.445 | |
| 4zas | TYD | CalS13 | / | 0.445 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.443 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.443 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.443 | |
| 1sre | HAB | Streptavidin | / | 0.442 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.442 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 2ejz | SAH | Diphthine synthase | / | 0.442 | |
| 2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.442 | |
| 4ckc | SAH | mRNA-capping enzyme catalytic subunit | 2.1.1.56 | 0.442 | |
| 2e1z | B4P | Propionate kinase | / | 0.441 | |
| 2z52 | H23 | Geranylgeranyl pyrophosphate synthase | / | 0.441 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.441 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.440 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 |