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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4lrjANPUncharacterized protein

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4lrjANPUncharacterized protein/1.000
4k8aK8AFocal adhesion kinase 12.7.10.20.493
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.489
3k5uPFQAurora kinase A2.7.11.10.488
4jajXU1Aurora kinase A2.7.11.10.486
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.475
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.475
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.474
5dnrATPAurora kinase A2.7.11.10.474
3efwAK8Aurora kinase A2.7.11.10.473
4deeADPAurora kinase A2.7.11.10.471
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.468
3cgfJNFMitogen-activated protein kinase 102.7.11.240.463
4f081RSTyrosine-protein kinase JAK2/0.459
2ijmATPFocal adhesion kinase 12.7.10.20.457
3i60E86Mitogen-activated protein kinase 12.7.11.240.457
1ig1ANPDeath-associated protein kinase 12.7.11.10.456
2xvdAS6Ephrin type-B receptor 42.7.10.10.456
3gu7ADPDeath-associated protein kinase 12.7.11.10.456
4jbpYPHAurora kinase A2.7.11.10.456
4o0uADNAurora kinase A2.7.11.10.456
5dt0SKEAurora kinase A2.7.11.10.456
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.454
4l9i8PRRhodopsin kinase/0.454
4fvqATPTyrosine-protein kinase JAK2/0.453
5dpvSKEAurora kinase A2.7.11.10.453
4eooATPCyclin-dependent kinase 22.7.11.220.452
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.452
3orpAGSSerine/threonine protein kinase/0.451
3ortAGSSerine/threonine protein kinase/0.451
1i44ACPInsulin receptor2.7.10.10.450
4dgmAGICasein kinase II subunit alpha2.7.11.10.450
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.450
5l8lADPAurora kinase A2.7.11.10.450
2henADPEphrin type-B receptor 22.7.10.10.449
4aqc88ATyrosine-protein kinase JAK2/0.449
4o1pANPRibonuclease L/0.449
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.449
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.448
4dt9GMPAPH(2'')-Id/0.448
4s33ANPMitogen-activated protein kinase 12.7.11.240.448
5dosATPAurora kinase A2.7.11.10.448
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.447
3zewSTUEphrin type-B receptor 42.7.10.10.447
4jia1K3Tyrosine-protein kinase JAK2/0.447
4o0wADNAurora kinase A2.7.11.10.447
4ix5ANPUncharacterized protein/0.446
4lfiGNPCasein kinase II subunit alpha2.7.11.10.445
2w4jADPDeath-associated protein kinase 12.7.11.10.444
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.444
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.444
4qmlANPSerine/threonine-protein kinase 242.7.11.10.444
1w8cN69Cyclin-dependent kinase 22.7.11.220.443
2j0lANPFocal adhesion kinase 12.7.10.20.443
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.443
4hge15VTyrosine-protein kinase JAK2/0.443
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.442
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
3lpbNVBTyrosine-protein kinase JAK2/0.441
3ztxZTXAurora kinase B-A2.7.11.10.441
4ji91M3Tyrosine-protein kinase JAK2/0.441
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.440
3c4wATPRhodopsin kinase/0.440
4btjATPTau-tubulin kinase 12.7.11.10.440
4hvi19STyrosine-protein kinase JAK32.7.10.20.440
4y95746Tyrosine-protein kinase/0.440