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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4jajXU1Aurora kinase A2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4jajXU1Aurora kinase A2.7.11.11.000
5dt0SKEAurora kinase A2.7.11.10.558
5dosATPAurora kinase A2.7.11.10.551
5dpvSKEAurora kinase A2.7.11.10.547
3k5uPFQAurora kinase A2.7.11.10.533
4o0wADNAurora kinase A2.7.11.10.517
5dr9SKEAurora kinase A2.7.11.10.513
4deeADPAurora kinase A2.7.11.10.507
4jbpYPHAurora kinase A2.7.11.10.496
4jboWPHAurora kinase A2.7.11.10.493
4deaNHIAurora kinase A2.7.11.10.488
5dr6SKEAurora kinase A2.7.11.10.487
4fv6E57Mitogen-activated protein kinase 12.7.11.240.485
3efwAK8Aurora kinase A2.7.11.10.482
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
4o0uADNAurora kinase A2.7.11.10.477
2pvlP55Casein kinase II subunit alpha2.7.11.10.476
5dnrATPAurora kinase A2.7.11.10.470
2dwbANPAurora kinase A2.7.11.10.469
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.469
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.469
2w1fL0FAurora kinase A2.7.11.10.468
4dgmAGICasein kinase II subunit alpha2.7.11.10.467
4c3pACPAurora kinase A2.7.11.10.466
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.466
5drdATPAurora kinase A2.7.11.10.466
2pvmP29Casein kinase II subunit alpha2.7.11.10.464
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.464
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.462
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.460
4fv9E71Mitogen-activated protein kinase 12.7.11.240.460
4jia1K3Tyrosine-protein kinase JAK2/0.459
3be9P04Casein kinase II subunit alpha2.7.11.10.458
3nynSGVG protein-coupled receptor kinase 62.7.11.160.458
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.458
4anmWULCasein kinase II subunit alpha2.7.11.10.456
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.455
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.454
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.453
2pvhP19Casein kinase II subunit alpha2.7.11.10.452
3i60E86Mitogen-activated protein kinase 12.7.11.240.451
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.451
4f081RSTyrosine-protein kinase JAK2/0.448
4hge15VTyrosine-protein kinase JAK2/0.448
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2a0cCK9Cyclin-dependent kinase 22.7.11.220.446
2btsU32Cyclin-dependent kinase 22.7.11.220.446
2ijmATPFocal adhesion kinase 12.7.10.20.446
5dt3ATPAurora kinase A2.7.11.10.444
3zewSTUEphrin type-B receptor 42.7.10.10.443
4aqc88ATyrosine-protein kinase JAK2/0.443
4dgnLU2Casein kinase II subunit alpha2.7.11.10.442
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.442
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.441
2j9mPY8Cyclin-dependent kinase 22.7.11.220.440
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.440
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.440