scPDB - Distribution of Cavity Similarity values of 4ixe entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4ixe	IXE	Dihydrofolate reductase	1.5.1.3

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	1.000
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.608
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.584
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.569
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.560
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.553
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.553
3cse	N22	Uncharacterized protein	/	0.551
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.549
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.547
3qlz	QLZ	Uncharacterized protein	/	0.547
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.546
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.544
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.541
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.540
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.540
3dg8	RJ6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.537
1ia2	TQ4	Dihydrofolate reductase	1.5.1.3	0.536
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.534
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.533
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.531
3qly	55V	Uncharacterized protein	/	0.531
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.531
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.530
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.529
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.529
1ia1	TQ3	Dihydrofolate reductase	1.5.1.3	0.528
3eem	53V	Uncharacterized protein	/	0.523
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.523
3qlx	QLR	Uncharacterized protein	/	0.523
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.521
3eek	53S	Uncharacterized protein	/	0.521
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.519
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.518
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.518
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.518
3eej	53R	Uncharacterized protein	/	0.515
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.514
3eel	53T	Uncharacterized protein	/	0.510
4h98	14Q	Uncharacterized protein	/	0.507
1ia3	TQ5	Dihydrofolate reductase	1.5.1.3	0.506
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.505
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	0.502
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.501
2w3v	TOP	Dihydrofolate reductase	/	0.501
3um8	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.501
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.500
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.500
1ai9	NDP	Dihydrofolate reductase	1.5.1.3	0.497
1m79	MQ1	Dihydrofolate reductase	1.5.1.3	0.496
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.496
3qlr	NDP	Dihydrofolate reductase	1.5.1.3	0.496
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.495
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.495
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.494
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.491
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.491
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.486
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.485
2h2q	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.484
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.484
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.482
3kjs	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.482
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.482
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.481
3qls	NDP	Dihydrofolate reductase	1.5.1.3	0.479
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.477
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.476
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.475
2zza	FOL	Dihydrofolate reductase	/	0.475
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.475
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.475
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.474
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.474
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.474
3dg8	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.472
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.471
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.470
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.468
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.466
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.466
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.466
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.464
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.464
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.463
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.459
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.457
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.457
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.456
3ia4	MTX	Dihydrofolate reductase	/	0.454
3sa1	6DR	Dihydrofolate reductase	/	0.454
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.454
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.451
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.450
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.449
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.449
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.447
1pkf	EPD	Epothilone C/D epoxidase	1.14	0.447
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.447
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.447
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.447
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.446
4p66	MTX	Dihydrofolate reductase	/	0.446
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.445
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.444
1q5d	EPB	Epothilone C/D epoxidase	1.14	0.444
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.443
3sh2	5DR	Dihydrofolate reductase	1.5.1.3	0.442
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.442
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.441
3jwc	EKB	Dihydrofolate reductase	/	0.441
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.441
2b37	8PS	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.440