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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hlm16STankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4hlm16STankyrase-22.4.2.301.000
4hkkAGITankyrase-22.4.2.300.680
4l31F08Tankyrase-22.4.2.300.650
4l0v1V1Tankyrase-22.4.2.300.631
4hl515WTankyrase-22.4.2.300.630
4bueJQFTankyrase-22.4.2.300.628
4buxF35Tankyrase-22.4.2.300.628
4kzl20DTankyrase-22.4.2.300.621
4hlf15ZTankyrase-22.4.2.300.620
4l33F70Tankyrase-22.4.2.300.620
4l2k1V8Tankyrase-22.4.2.300.617
4l0i1UWTankyrase-22.4.2.300.616
4bus32FTankyrase-22.4.2.300.615
4l2f1V3Tankyrase-22.4.2.300.615
4l0s1UZTankyrase-22.4.2.300.614
4iueAJ4Tankyrase-22.4.2.300.611
4avwG18Tankyrase-22.4.2.300.610
4bud29FTankyrase-22.4.2.300.610
4bufF36Tankyrase-22.4.2.300.606
4l321VFTankyrase-22.4.2.300.606
5aku29FTankyrase-22.4.2.300.605
4l2g1V4Tankyrase-22.4.2.300.603
4hlh20DTankyrase-22.4.2.300.596
4j21AJ6Tankyrase-22.4.2.300.596
4bu908CTankyrase-22.4.2.300.595
4j22AJ7Tankyrase-22.4.2.300.589
4buwF33Tankyrase-22.4.2.300.586
4hmhF94Tankyrase-22.4.2.300.585
4pnrG18Tankyrase-22.4.2.300.582
4buuF38Tankyrase-22.4.2.300.578
4bs4A64Tankyrase-22.4.2.300.576
4bj9UHBTankyrase-22.4.2.300.569
3p0pNNFTankyrase-22.4.2.300.560
4krs1SXTankyrase-12.4.2.300.560
4hkiFLNTankyrase-22.4.2.300.558
4but31FTankyrase-22.4.2.300.557
4tkg09LTankyrase-22.4.2.300.543
4l091URTankyrase-22.4.2.300.540
4bjbP34Tankyrase-22.4.2.300.517
4pnmNU1Tankyrase-22.4.2.300.511
4msk2C8Tankyrase-12.4.2.300.509
4hyf1AKTankyrase-22.4.2.300.501
4i9i1DYTankyrase-12.4.2.300.500
4buv16ITankyrase-22.4.2.300.498
4avuLDRTankyrase-22.4.2.300.497
4tjy3GNTankyrase-22.4.2.300.491
4j3lAJ5Tankyrase-22.4.2.300.484
4k4eK4ETankyrase-12.4.2.300.474
4mt92D6Tankyrase-12.4.2.300.461
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.452
1xk9P34Exotoxin A2.4.2.360.451
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.444
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.444
2dw4FADLysine-specific histone demethylase 1A10.443
3b82NADExotoxin A2.4.2.360.442
4k4fK4FTankyrase-12.4.2.300.442
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.442
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.440
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.440