Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.10

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.101.000
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.100.810
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.653
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.640
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.609
3iczPB6Farnesyl pyrophosphate synthase/0.578
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.100.561
1zw5ZOLFarnesyl pyrophosphate synthase2.5.1.100.548
3egt722Farnesyl pyrophosphate synthase/0.547
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.536
4kqsRISFarnesyl pyrophosphate synthase2.5.1.100.536
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.100.513
2opnSUFFarnesyl pyrophosphate synthase2.5.1.100.504
3dyh721Farnesyl pyrophosphate synthase/0.503
3rywK9HFarnesyl pyrophosphate synthase, putative/0.500
3ez3ZOLFarnesyl pyrophosphate synthase, putative/0.499
1rqjRISFarnesyl diphosphate synthase2.5.1.100.495
3oabDSTGeranyl diphosphate synthase large subunit/0.475
1rx8NAPDihydrofolate reductase1.5.1.30.469
1q6t600Tyrosine-protein phosphatase non-receptor type 13.1.3.480.467
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
3krfDSTGeranyl diphosphate synthase large subunit/0.459
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.458
1rx1NAPDihydrofolate reductase1.5.1.30.454
2ekaSAHDiphthine synthase/0.454
2xlrFADPutative flavin-containing monooxygenase/0.453
5iqiGNPBifunctional AAC/APH2.3.10.453
2p6dSAHDiphthine synthase/0.451
2dv5SAHDiphthine synthase/0.449
3q8uADPNucleoside diphosphate kinase/0.449
2ehlSAHDiphthine synthase/0.447
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.447
2ylzFADPhenylacetone monooxygenase1.14.13.920.446
1s3vTQDDihydrofolate reductase1.5.1.30.445
3dagFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.445
2dv7SAHDiphthine synthase/0.444
2p5fSAHDiphthine synthase/0.444
3nga3NGCasein kinase II subunit alpha2.7.11.10.444
5jqbIBPEnvelope glycoprotein/0.444
1dr3HBIDihydrofolate reductase1.5.1.30.443
4blsAPCNTPase P4/0.443
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4l4xNDPAmphI/0.443
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.442
3qtxX43Cyclin-dependent kinase 22.7.11.220.442
4bftZVTPantothenate kinase2.7.1.330.442
1n83CLRNuclear receptor ROR-alpha/0.441
1rd4L08Integrin alpha-L/0.441
1vceSAHDiphthine synthase/0.441
2owuSAHDiphthine synthase/0.441
3t88S0N1,4-dihydroxy-2-naphthoyl-CoA synthase/0.441
3w8dNAD3-hydroxybutyrate dehydrogenase/0.441
2e15SAHDiphthine synthase/0.440
2emuSAHDiphthine synthase/0.440
2owkSAHDiphthine synthase/0.440
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.440
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.440
3gqvNAPEnoyl reductase LovC10.440
3py0SU9Cyclin-dependent kinase 22.7.11.220.440
5eccNAPDehydrofolate reductase type I/0.440