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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fvqATPTyrosine-protein kinase JAK2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fvqATPTyrosine-protein kinase JAK2/1.000
5i4nATPTyrosine-protein kinase JAK2/0.558
4fvrATPTyrosine-protein kinase JAK2/0.539
4lrjANPUncharacterized protein/0.490
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.482
2qo7ANPEphrin type-A receptor 32.7.10.10.467
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.463
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.462
3r1yX76Cyclin-dependent kinase 22.7.11.220.461
2henADPEphrin type-B receptor 22.7.10.10.459
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.457
2qoqANPEphrin type-A receptor 32.7.10.10.457
2qo9ANPEphrin type-A receptor 32.7.10.10.455
1i44ACPInsulin receptor2.7.10.10.454
1dawANPCasein kinase II subunit alpha2.7.11.10.453
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.453
4o1pANPRibonuclease L/0.453
2xa4AZ5Tyrosine-protein kinase JAK2/0.452
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.452
2qw034Z4-chlorobenzoyl CoA ligase/0.451
4e6q0NVTyrosine-protein kinase JAK2/0.451
4tuvCPZCytochrome P450 1191.140.451
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.450
2d1cNAPIsocitrate dehydrogenase [NADP]1.1.1.420.450
5e92ANPTGF-beta receptor type-22.7.11.300.450
3c1y2BADNA integrity scanning protein DisA/0.449
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.448
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.447
1qmzATPCyclin-dependent kinase 22.7.11.220.447
4aqc88ATyrosine-protein kinase JAK2/0.447
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.446
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.446
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4hge15VTyrosine-protein kinase JAK2/0.446
4yp12BAStimulator of interferon genes protein/0.446
1vfrFMNMajor NAD(P)H-flavin oxidoreductase1.6.990.445
4bfzZVZPantothenate kinase2.7.1.330.445
1a5uATPPyruvate kinase PKM2.7.1.400.442
1oonFMNOxygen-insensitive NAD(P)H nitroreductase/0.442
2xy3DUPSPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS3.6.1.230.442
3e8nVRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.442
3tqhNDPQuinone oxidoreductase/0.442
4kgmATPUncharacterized protein/0.442
1f28UMPThymidylate synthase2.1.1.450.441
1xelUPGUDP-glucose 4-epimerase5.1.3.20.441
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.441
3lpbNVBTyrosine-protein kinase JAK2/0.441
4zseANPEpidermal growth factor receptor2.7.10.10.441
2hckQUETyrosine-protein kinase HCK2.7.10.20.440
2qocANPEphrin type-A receptor 32.7.10.10.440
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.440
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.440
5cvcPLPSerine racemase/0.440