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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fv5EK9Mitogen-activated protein kinase 12.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fv5EK9Mitogen-activated protein kinase 12.7.11.241.000
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.613
3i60E86Mitogen-activated protein kinase 12.7.11.240.598
4fv6E57Mitogen-activated protein kinase 12.7.11.240.590
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.534
4fv9E71Mitogen-activated protein kinase 12.7.11.240.505
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.495
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.494
2uzbC75Cyclin-dependent kinase 22.7.11.220.489
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.486
4qnyANPMitogen activated protein kinase, putative/0.480
4btjATPTau-tubulin kinase 12.7.11.10.477
3my5RFZCyclin-dependent kinase 22.7.11.220.475
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.472
5e8ySTUTGF-beta receptor type-22.7.11.300.471
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.470
3be9P04Casein kinase II subunit alpha2.7.11.10.469
3nieANPMitogen-activated protein kinase/0.465
4jia1K3Tyrosine-protein kinase JAK2/0.465
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.464
4ii5ADPCyclin-dependent kinase 22.7.11.220.464
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.463
2yaaATPDeath-associated protein kinase 2/0.462
4aqc88ATyrosine-protein kinase JAK2/0.462
4f081RSTyrosine-protein kinase JAK2/0.462
4hge15VTyrosine-protein kinase JAK2/0.462
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.460
3nynSGVG protein-coupled receptor kinase 62.7.11.160.460
4btjADPTau-tubulin kinase 12.7.11.10.459
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.456
1qmzATPCyclin-dependent kinase 22.7.11.220.455
2vu3LZECyclin-dependent kinase 22.7.11.220.454
4h3qANPMitogen-activated protein kinase 12.7.11.240.453
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.452
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.450
3gu83GUDeath-associated protein kinase 12.7.11.10.449
3s1h56ZCyclin-dependent kinase 22.7.11.220.449
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.449
4eooATPCyclin-dependent kinase 22.7.11.220.448
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.448
5dosATPAurora kinase A2.7.11.10.448
2ojj82AMitogen-activated protein kinase 12.7.11.240.445
3dfcANPDeath-associated protein kinase 12.7.11.10.444
4dgnLU2Casein kinase II subunit alpha2.7.11.10.444
2pvmP29Casein kinase II subunit alpha2.7.11.10.443
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4grb0XGCasein kinase II subunit alpha2.7.11.10.443
3at4CCKCasein kinase II subunit alpha2.7.11.10.442
3rkb12ZCyclin-dependent kinase 22.7.11.220.442
4bcmT7ZCyclin-dependent kinase 22.7.11.220.442
4qmlANPSerine/threonine-protein kinase 242.7.11.10.442
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.440
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.440
3lltANPProtein serine/threonine kinase-1/0.440
4ehzJAKTyrosine-protein kinase JAK1/0.440
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.440
4j95ACPFibroblast growth factor receptor 2/0.440