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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.21.000
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.563
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.546
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.518
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.517
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.509
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.508
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.508
4nka2K7Fibroblast growth factor receptor 1/0.508
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.499
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.499
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.492
1k6cMK1Gag-Pol polyprotein3.4.23.160.489
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.487
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.486
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.485
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.480
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.479
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.479
2c6eHPMAurora kinase A2.7.11.10.476
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.476
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.472
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.472
3vs3VSETyrosine-protein kinase HCK2.7.10.20.472
4f640S8Fibroblast growth factor receptor 1/0.472
3vs1VSATyrosine-protein kinase HCK2.7.10.20.471
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.471
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.470
4j1tNADNAD/NADP transhydrogenase alpha subunit 1/0.470
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.470
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.470
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.470
1k6pXN3Gag-Pol polyprotein3.4.23.160.469
3vryB43Tyrosine-protein kinase HCK2.7.10.20.469
3icrCOACoenzyme A disulfide reductase/0.468
3zewSTUEphrin type-B receptor 42.7.10.10.468
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.467
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.467
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.466
1k6vXN2Gag-Pol polyprotein3.4.23.160.464
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.464
4nk92K5Fibroblast growth factor receptor 1/0.464
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
1w1rZEACytokinin dehydrogenase 11.5.99.120.461
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.459
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.459
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.458
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.457
4z9rNADOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.457
4an35Y0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.456
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.456
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
3gc8B45Mitogen-activated protein kinase 112.7.11.240.455
3w2sW2REpidermal growth factor receptor2.7.10.10.455
4hjoAQ4Epidermal growth factor receptor2.7.10.10.455
3l8p0CEAngiopoietin-1 receptor2.7.10.10.454
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
3w2o03PEpidermal growth factor receptor2.7.10.10.453
4id71G0Activated CDC42 kinase 1/0.452
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
2fgiPD1Fibroblast growth factor receptor 1/0.450
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.450
2pwuGUNQueuine tRNA-ribosyltransferase2.4.2.290.450
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.450
2j7t274Serine/threonine-protein kinase 102.7.11.10.449
3t113T1Gag-Pol polyprotein3.4.23.160.449
4fob0USALK tyrosine kinase receptor2.7.10.10.449
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.448
4n9wGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.448
3uvqFS8Mitogen-activated protein kinase 14/0.447
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.447
4g1wG1WMitogen-activated protein kinase 82.7.11.240.447
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.446
2a0cCK9Cyclin-dependent kinase 22.7.11.220.445
4aotGW8Serine/threonine-protein kinase 102.7.11.10.445
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3w33W19Epidermal growth factor receptor2.7.10.10.443
3gc9B45Mitogen-activated protein kinase 112.7.11.240.442
3qlrNDPDihydrofolate reductase1.5.1.30.441
5f8eSAHPossible transcriptional regulatory protein/0.441
3s1cZIRCytokinin dehydrogenase 11.5.99.120.440