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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eooATPCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4eooATPCyclin-dependent kinase 22.7.11.221.000
4ii5ADPCyclin-dependent kinase 22.7.11.220.585
1qmzATPCyclin-dependent kinase 22.7.11.220.541
2uzbC75Cyclin-dependent kinase 22.7.11.220.526
2cjmATPCyclin-dependent kinase 22.7.11.220.522
3my5RFZCyclin-dependent kinase 22.7.11.220.518
4i3zADPCyclin-dependent kinase 22.7.11.220.516
3gu7ADPDeath-associated protein kinase 12.7.11.10.503
4bcmT7ZCyclin-dependent kinase 22.7.11.220.503
2cciATPCyclin-dependent kinase 22.7.11.220.491
4qnyANPMitogen activated protein kinase, putative/0.488
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.487
1fvv107Cyclin-dependent kinase 22.7.11.220.483
3nux3NVCyclin-dependent kinase 62.7.11.220.483
4c3pACPAurora kinase A2.7.11.10.475
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.472
2uzdC85Cyclin-dependent kinase 22.7.11.220.470
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.466
5dosATPAurora kinase A2.7.11.10.466
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.465
5av2KMPDeath-associated protein kinase 12.7.11.10.465
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.464
3i60E86Mitogen-activated protein kinase 12.7.11.240.462
4fv6E57Mitogen-activated protein kinase 12.7.11.240.462
4s33ANPMitogen-activated protein kinase 12.7.11.240.462
4jia1K3Tyrosine-protein kinase JAK2/0.461
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.458
4btjATPTau-tubulin kinase 12.7.11.10.458
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.456
4deeADPAurora kinase A2.7.11.10.456
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.455
2vv9IM9Cyclin-dependent kinase 22.7.11.220.454
5dnrATPAurora kinase A2.7.11.10.453
3c4wATPRhodopsin kinase/0.452
4fv9E71Mitogen-activated protein kinase 12.7.11.240.452
1ig1ANPDeath-associated protein kinase 12.7.11.10.450
1jkkANPDeath-associated protein kinase 12.7.11.10.450
4aqc88ATyrosine-protein kinase JAK2/0.449
4l9i8PRRhodopsin kinase/0.449
5eg3ACPFibroblast growth factor receptor 2/0.449
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.447
3s1h56ZCyclin-dependent kinase 22.7.11.220.446
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
1jstATPCyclin-dependent kinase 22.7.11.220.441
3rak03ZCyclin-dependent kinase 22.7.11.220.441
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.440
5aut2ANDeath-associated protein kinase 12.7.11.10.440