sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4eet | FMN | Phototropin-2 | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4eet | FMN | Phototropin-2 | 2.7.11.1 | 1.000 | |
| 2z6d | FMN | Phototropin-2 | 2.7.11.1 | 0.587 | |
| 3t50 | FMN | Blue-light-activated histidine kinase | 2.7.13.3 | 0.551 | |
| 2pr5 | FMN | Blue-light photoreceptor | / | 0.534 | |
| 3p7n | FMN | Light-activated DNA-binding protein EL222 | / | 0.510 | |
| 3ue6 | FMN | Aureochrome1 | / | 0.507 | |
| 1n9n | FMN | Putative blue light receptor | / | 0.506 | |
| 5dkk | FMN | Predicted protein | / | 0.504 | |
| 3is2 | FAD | Vivid PAS protein VVD | / | 0.502 | |
| 4hia | FMN | LOV protein | / | 0.499 | |
| 4eeu | FMN | Phototropin-2 | 2.7.11.1 | 0.494 | |
| 4hj6 | FMN | LOV protein | / | 0.494 | |
| 3sw1 | FMN | Sensory box protein | / | 0.492 | |
| 4eep | FMN | Phototropin-2 | 2.7.11.1 | 0.492 | |
| 4hhd | FMN | Phototropin-1 | 2.7.11.1 | 0.492 | |
| 4ees | FMN | Phototropin-2 | 2.7.11.1 | 0.490 | |
| 5djt | FMN | NPH1-2 | / | 0.487 | |
| 2pd8 | FAD | Vivid PAS protein VVD | / | 0.486 | |
| 2z6c | FMN | Phototropin-1 | 2.7.11.1 | 0.481 | |
| 5efw | FMN | NPH1-1 | / | 0.481 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.476 | |
| 4eer | FMN | Phototropin-2 | 2.7.11.1 | 0.467 | |
| 1n9l | FMN | Putative blue light receptor | / | 0.465 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.465 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 2pd7 | FAD | Vivid PAS protein VVD | / | 0.462 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.461 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.460 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.458 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.458 | |
| 4iah | 1DX | Alr2278 protein | / | 0.457 | |
| 1i3m | UD1 | UDP-glucose 4-epimerase | / | 0.453 | |
| 2v1a | FMN | NPH1-1 | / | 0.452 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.452 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.451 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.451 | |
| 5j4e | FMN | Sensory box protein | / | 0.451 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.450 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.449 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.449 | |
| 2xvv | 9DN | Serum albumin | / | 0.448 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.448 | |
| 5j3w | FMN | Sensory box protein | / | 0.448 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1p9w | ANP | Type II secretion system protein E | / | 0.447 | |
| 2xvw | 9NR | Serum albumin | / | 0.447 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.446 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 1xkd | NAP | Isocitrate dehydrogenase [NADP] | / | 0.445 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.445 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.444 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.444 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.443 | |
| 2g37 | FAD | Proline dehydrogenase | / | 0.443 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.443 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.442 | |
| 4kuk | RBF | Putative blue-light photoreceptor | / | 0.442 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.441 | |
| 2ejz | SAH | Diphthine synthase | / | 0.441 | |
| 2v0u | FMN | NPH1-1 | / | 0.441 | |
| 4jld | ADP | Adenylate kinase | / | 0.441 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.441 | |
| 4m55 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.441 | |
| 4r38 | RBF | Blue-light-activated histidine kinase 2 | 2.7.13.3 | 0.441 | |
| 5ez7 | FAD | Probable FAD-dependent oxidoreductase PA4991 | / | 0.441 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.440 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.440 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.440 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.440 |