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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e5oUMPThymidylate synthase2.1.1.45

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4e5oUMPThymidylate synthase2.1.1.451.000
4einNOHThymidylate synthase2.1.1.450.644
4eb4UMPThymidylate synthase2.1.1.450.608
4irrUMPThymidylate synthase/0.577
5by6UMPThymidylate synthase/0.577
4dq1UMPThymidylate synthase/0.575
2g89UMPThymidylate synthase/0.568
4psgNOHThymidylate synthase/0.563
1njcDCMThymidylate synthase/0.559
3qj7UMPThymidylate synthase ThyA/0.556
1jmiUMPThymidylate synthase/0.553
4h0uUMPThymidylate synthase/0.551
1njdUMPThymidylate synthase/0.548
3hb8UMPThymidylate synthase2.1.1.450.543
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.543
1bidUMPThymidylate synthase/0.542
1tsvUMPThymidylate synthase/0.539
2g8dUMPThymidylate synthase/0.538
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.537
1bp6UMPThymidylate synthase/0.536
2g86UMPThymidylate synthase/0.535
4xsdUMPThymidylate synthase2.1.1.450.532
1njbUMPThymidylate synthase/0.530
1thyUMPThymidylate synthase/0.529
1bduDURThymidylate synthase/0.524
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.520
1dduDDUThymidylate synthase/0.519
1jmhUMPThymidylate synthase/0.519
1tsyUMPThymidylate synthase/0.516
1jmgUMPThymidylate synthase/0.514
1dduCB3Thymidylate synthase/0.511
1njeDCMThymidylate synthase/0.511
1bp0UMPThymidylate synthase/0.507
1ci7UMPThymidylate synthase2.1.1.450.507
1tsxUMPThymidylate synthase/0.507
4fogC2FThymidylate synthase ThyA/0.501
2vetUMPThymidylate synthase/0.497
1njaDCMThymidylate synthase/0.496
4ez8DHFThymidylate synthase2.1.1.450.495
1f4eTPRThymidylate synthase/0.493
2tddTHFThymidylate synthase/0.492
1bpjUMPThymidylate synthase/0.489
3bhrTHGThymidylate synthase/0.489
2vf0F89Thymidylate synthase/0.486
1an5CB3Thymidylate synthase/0.477
1vzaUMPThymidylate synthase/0.471
4lrrCF9Thymidylate synthase/0.471
2tsrUMPThymidylate synthase2.1.1.450.469
1lcbTMPThymidylate synthase/0.468
3bgxTMPThymidylate synthase/0.465
4iskUMPThymidylate synthase/0.464
1lcbDHFThymidylate synthase/0.462
1tdcUMPThymidylate synthase/0.461
3bgxMEFThymidylate synthase/0.456
4foxUMPThymidylate synthase ThyA/0.448
4knzCB3Thymidylate synthase/0.447
1vzdCB3Thymidylate synthase/0.446
1f4fTP3Thymidylate synthase/0.445
1fwmCB3Thymidylate synthase/0.445
1j3jUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
1tduDURThymidylate synthase/0.440