sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3sw8 | 5LI | Peptide deformylase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3sw8 | 5LI | Peptide deformylase | / | 1.000 | |
| 3svj | 4LI | Peptide deformylase | / | 0.517 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.516 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.482 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.471 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.469 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.467 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.462 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.459 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.456 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.456 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.455 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.454 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.453 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.451 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.451 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.450 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 4gt3 | ATP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.449 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.448 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.448 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 3qts | X46 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 4ie6 | UN9 | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.446 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.446 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.446 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.445 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4xq9 | NAD | Homospermidine synthase | 2.5.1.44 | 0.445 | |
| 4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.445 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.444 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.443 | |
| 4dp3 | MMV | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.442 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.442 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.441 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.441 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.441 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.440 | |
| 2jih | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | 3.4.24 | 0.440 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4qo9 | 627 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.440 |