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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3s6gCOAN-acetylglutamate kinase / N-acetylglutamate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3s6gCOAN-acetylglutamate kinase / N-acetylglutamate synthase/1.000
3s1aATPCircadian clock protein kinase KaiC2.7.11.10.479
1touB1VFatty acid-binding protein, adipocyte/0.465
1unhIXMCyclin-dependent-like kinase 52.7.11.10.464
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4bcpT3CCyclin-dependent kinase 22.7.11.220.458
2j9gADPBiotin carboxylase6.3.4.140.456
2yj4ATPCopper-transporting ATPase/0.455
2yecXQ0Heat shock protein HSP 90-alpha/0.452
1gy3ATPCyclin-dependent kinase 22.7.11.220.451
1towCRZFatty acid-binding protein, adipocyte/0.450
2xf3J01Uncharacterized protein/0.450
2y9qANPMitogen-activated protein kinase 12.7.11.240.450
1szcCNANAD-dependent protein deacetylase HST23.5.10.449
2ye42FYHeat shock protein HSP 90-alpha/0.449
2byi2DDHeat shock protein HSP 90-alpha/0.448
4el5D1MGlycogen phosphorylase, muscle form2.4.1.10.448
1osfKOSHeat shock protein HSP 90-alpha/0.447
3lfqA28Cyclin-dependent kinase 22.7.11.220.447
4xdmGDMHeat shock cognate 90 kDa protein/0.447
2yi66QMHeat shock protein HSP 90-alpha/0.446
3k0aATPCircadian clock protein kinase KaiC2.7.11.10.446
3ojiPYVAbscisic acid receptor PYL3/0.446
1j39UPGDNA beta-glucosyltransferase/0.445
3r8lZ30Cyclin-dependent kinase 22.7.11.220.445
3qttANPPantothenate synthetase/0.444
4la7A1OAbscisic acid receptor PYL2/0.444
2xvdAS6Ephrin type-B receptor 42.7.10.10.443
4fxy0W2Neurolysin, mitochondrial3.4.24.160.443
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.442
3juqAJDPhenazine biosynthesis protein A/B/0.442
3mjrAC2Deoxycytidine kinase2.7.1.740.442
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.442
2bzsCB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.441
4g8jTHMUridine phosphorylase/0.441
3s6aANPAdenosine monophosphate-protein transferase NmFic2.7.7.n10.440
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.440
4ea30NNNociceptin receptor/0.440