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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3k4vROCGag-Pol polyprotein3.4.23.16

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
3k4vROCGag-Pol polyprotein3.4.23.161.000
3ndtROCGag-Pol polyprotein3.4.23.160.733
2pk5075Protease/0.665
1rl8RITGag-Pol polyprotein3.4.23.160.634
3ggaGGWGag-Pol polyprotein/0.622
4a4qUX9Pol protein/0.622
3zpsEQMGag-Pol polyprotein3.4.23.160.616
2cem2AHPol protein/0.613
1hvkA79Gag-Pol polyprotein/0.610
3hzc2NCProtease/0.610
3oxcROCProtease/0.610
4hdfG52Gag-Pol polyprotein3.4.23.160.610
2aoe0Q4Gag-Pol polyprotein3.4.23.160.607
3tl9ROCGag-Pol polyprotein3.4.23.160.605
1ec2BEJGag-Pol polyprotein3.4.23.160.602
1hvsA77Gag-Pol polyprotein/0.602
1difA85Gag-Pol polyprotein/0.599
3em4DR7Gag-Pol polyprotein3.4.23.160.598
1hvlA76Gag-Pol polyprotein/0.597
3pwrROCGag-Pol polyprotein3.4.23.160.596
2uxzHI1Gag-Pol polyprotein3.4.23.160.595
2xyfG40Gag-Pol polyprotein/0.595
3bxsDRSGag-Pol polyprotein3.4.23.160.594
2pk6O33V-1 protease/0.593
1w5xBE5Gag-Pol polyprotein3.4.23.160.591
1hvjA78Gag-Pol polyprotein/0.589
2nmyROCProtease/0.589
3zptM8YGag-Pol polyprotein3.4.23.160.589
1d4yTPVGag-Pol polyprotein3.4.23.160.587
3a2oKNJGag-Pol polyprotein3.4.23.160.585
3ndwRITGag-Pol polyprotein3.4.23.160.585
3ndxRITGag-Pol polyprotein3.4.23.160.585
3d1yROCGag-Pol polyprotein3.4.23.160.584
2bqvA1AProtease/0.583
2uy0HV1Gag-Pol polyprotein3.4.23.160.583
3i2l2NCProtease/0.583
1hxbROCGag-Pol polyprotein3.4.23.160.582
1zsr0ZTGag-Pol polyprotein3.4.23.160.582
1ivp1ZKGag-Pol polyprotein/0.581
2a4fAAUV-1 protease/0.581
2fxeDR7Gag-Pol polyprotein3.4.23.160.581
2nnkROCProtease/0.581
1w5yBE6Gag-Pol polyprotein3.4.23.160.580
4qgiROCGag-Pol polyprotein3.4.23.160.580
2aquDR7Gag-Pol polyprotein3.4.23.160.579
3kdcJZPGag-Pol polyprotein3.4.23.160.578
2f3kRO1Protease/0.577
2xyeCXGGag-Pol polyprotein/0.577
2qd6065Gag-Pol polyprotein3.4.23.160.576
1ec3MS3Gag-Pol polyprotein3.4.23.160.575
4kb9G79Protease/0.575
3sa323XProtease/0.574
3d1xROCGag-Pol polyprotein3.4.23.160.572
3gi6D78Gag-Pol polyprotein/0.572
1b6pPI7Gag-Pol polyprotein3.4.23.160.571
3ok9G52Gag-Pol polyprotein3.4.23.160.571
2qi3MZ5Gag-Pol polyprotein/0.570
3ekp478Gag-Pol polyprotein3.4.23.160.570
2idw017Protease/0.569
2qi6MZ8Gag-Pol polyprotein/0.569
4djoMK5Pol polyprotein/0.569
2cen4AHProtease/0.568
2fdd385Pol protein/0.567
3ekqROCGag-Pol polyprotein3.4.23.160.567
3nduROCGag-Pol polyprotein3.4.23.160.567
3bva2NCGag-Pol polyprotein3.4.23.160.566
1dw60Q4Gag-Pol polyprotein3.4.23.160.565
1ohr1UNV-1 PROTEASE protein/0.565
3zpuM8BGag-Pol polyprotein3.4.23.160.565
1ebwBEIGag-Pol polyprotein3.4.23.160.564
1z1hHBBGag-Pol polyprotein3.4.23.160.564
2q5kAB1Protease/0.564
3ggxGGXGag-Pol polyprotein/0.564
3nxe2NCProtease/0.564
3mxeK54Gag-Pol polyprotein3.4.23.160.562
3sa5A69Protease/0.562
3sa755AProtease/0.562
1iiq0ZRGag-Pol polyprotein3.4.23.160.561
2f81017Gag-Pol polyprotein3.4.23.160.561
2p3b3TLV-1 PROTEASE protein/0.561
2p3b3TLV-1 protease/0.561
2upjU02Gag-Pol polyprotein3.4.23.160.561
2wkz5AHGag-Pol polyprotein/0.561
3dk1G05Gag-Pol polyprotein3.4.23.160.561
3sabF78Protease/0.561
1a8k0Q4Gag-Pol polyprotein3.4.23.160.560
3s56ROCProtease/0.560
4djpM73Pol polyprotein/0.560
4hdbG52Gag-Pol polyprotein3.4.23.160.560
1mtrPI6Gag-Pol polyprotein3.4.23.160.559
2bpv1INGag-Pol polyprotein3.4.23.160.559
2ieo017Protease/0.559
3qn8NI7Gag-Pol polyprotein3.4.23.160.559
1ec1BEEGag-Pol polyprotein3.4.23.160.557
1yt9OISGag-Pol polyprotein/0.557
2a1eIPFGag-Pol polyprotein3.4.23.160.557
3el4ROCGag-Pol polyprotein3.4.23.160.557
3nyg2NCGag-Pol polyprotein3.4.23.160.557
3sa4F72Protease/0.556
1hiv1ZKGag-Pol polyprotein/0.555
1k1u0Q4Gag-Pol polyprotein3.4.23.160.555
3kfr3TLGag-Pol polyprotein/0.555
3s85LK0Gag-Pol polyprotein/0.555
4njvRITProtease/0.554
1vikBAYGag-Pol polyprotein/0.553
2pyn1UNGag-Pol polyprotein3.4.23.160.553
3cyxROCGag-Pol polyprotein3.4.23.160.553
3vf5031Gag-Pol polyprotein3.4.23.160.553
4djr0KJPol polyprotein/0.553
2fde385Gag-Pol polyprotein3.4.23.160.552
3sa6F71Protease/0.552
3sacAF8Protease/0.552
4hdpG52Gag-Pol polyprotein3.4.23.160.552
2b7zMK1Gag-Pol polyprotein/0.551
1ffi2NCGag-Pol polyprotein3.4.23.160.550
3kfs3TLGag-Pol polyprotein/0.550
3o9bK2APol polyprotein/0.550
3o9cK20Pol polyprotein/0.550
3linE13Protease/0.549
4djqM86Pol polyprotein/0.549
3oxxDR7Gag-Pol polyprotein3.4.23.160.548
1hviA77Protease/0.547
3ekyDR7Gag-Pol polyprotein3.4.23.160.547
3kf03TLGag-Pol polyprotein/0.547
1d4sTPVGag-Pol polyprotein3.4.23.160.546
1z1rHBHGag-Pol polyprotein3.4.23.160.546
2bpz3INGag-Pol polyprotein3.4.23.160.546
3jw2017Gag-Pol polyprotein3.4.23.160.546
4ye3G04Gag-Pol polyprotein3.4.23.160.546
1hihC20Gag-Pol polyprotein/0.545
1hosPHPGag-Pol polyprotein/0.545
1hxwRITGag-Pol polyprotein/0.545
1ida0POGag-Pol polyprotein3.4.23.470.544
2bpy3INGag-Pol polyprotein3.4.23.160.544
2fleAIProtease/0.544
3el9DR7Gag-Pol polyprotein3.4.23.160.544
1iziQ50Gag-Pol polyprotein3.4.23.160.543
1sbgIM1Gag-Pol polyprotein/0.543
2bpw1INGag-Pol polyprotein3.4.23.160.543
3nwq2NCGag-Pol polyprotein3.4.23.160.543
1ff02NCGag-Pol polyprotein3.4.23.160.542
1fgc2NCGag-Pol polyprotein3.4.23.160.542
1t7i017Gag-Pol polyprotein3.4.23.160.542
2ien017Gag-Pol polyprotein3.4.23.160.542
2q54MU1Protease/0.542
3kfn3TLGag-Pol polyprotein/0.542
3dcrKVSProtease/0.541
1izhQ50Protease/0.540
3ekt017Gag-Pol polyprotein3.4.23.160.540
3el1DR7Gag-Pol polyprotein3.4.23.160.540
1jld0PPGag-Pol polyprotein/0.539
1vijBAYGag-Pol polyprotein/0.539
2qd8065Gag-Pol polyprotein3.4.23.160.539
4dqe017Gag-Pol polyprotein/0.539
1k2b0Q4Gag-Pol polyprotein3.4.23.160.538
1odw0E8Gag-Pol polyprotein3.4.23.160.538
2avvMK1Gag-Pol polyprotein3.4.23.160.538
2nnpROCProtease/0.538
3tog079Gag-Pol polyprotein2.7.7.490.538
1sdvMK1Gag-Pol polyprotein3.4.23.160.537
4a6bQG8Gag-Pol polyprotein3.4.23.160.537
4j55031Gag-Pol polyprotein3.4.23.160.537
1ebzBECGag-Pol polyprotein3.4.23.160.536
2avm2NCGag-Pol polyprotein3.4.23.160.536
3o9fK2DGag-Pol polyprotein/0.536
3vfa031Gag-Pol polyprotein3.4.23.160.535
1b6lPI4Gag-Pol polyprotein3.4.23.160.534
4rvj478Protease/0.534
3jvy017Gag-Pol polyprotein3.4.23.160.533
3o9eA60Pol polyprotein/0.533
4dqc017Gag-Pol polyprotein/0.533
1a9mU0EGag-Pol polyprotein/0.532
1b6mPI6Gag-Pol polyprotein3.4.23.160.532
1wbk568Pol protein/0.532
2qd7065Gag-Pol polyprotein3.4.23.160.532
2wl05AHGag-Pol polyprotein/0.532
1fg80Q4Gag-Pol polyprotein3.4.23.160.531
3ekwDR7Gag-Pol polyprotein3.4.23.160.531
3st5G89Gag-Pol polyprotein3.4.23.160.531
2i4xKGQProtease/0.530
2p3d3TLProtease/0.530
3vfb031Gag-Pol polyprotein3.4.23.160.530
1a940Q4Gag-Pol polyprotein3.4.23.160.529
1c6zROCProtease/0.529
1zsf0ZSGag-Pol polyprotein3.4.23.160.529
2qi5MZ7Gag-Pol polyprotein/0.529
2qnpQN2Gag-Pol polyprotein3.4.23.160.529
3jvwDMPGag-Pol polyprotein3.4.23.160.529
3qrsNK8Gag-Pol polyprotein3.4.23.160.529
3sa9A68Protease/0.529
1daz0Q4Gag-Pol polyprotein3.4.23.160.528
3el51UNGag-Pol polyprotein/0.528
3em6017Gag-Pol polyprotein3.4.23.160.528
3gi4K60Gag-Pol polyprotein/0.528
3oxv478Gag-Pol polyprotein3.4.23.160.528
3nu9478Gag-Pol polyprotein3.4.23.160.527
3ttp017Gag-Pol polyprotein3.4.23.160.527
1m0b0ZQGag-Pol polyprotein3.4.23.160.526
1xl5190Gag-Pol polyprotein3.4.23.160.526
2o4pTPVProtease/0.526
3qbfJHGGag-Pol polyprotein3.4.23.160.526
1n49RITGag-Pol polyprotein3.4.23.160.525
1wbmBLLPol protein/0.525
1d4iBEGGag-Pol polyprotein3.4.23.160.524
1fej2NCGag-Pol polyprotein3.4.23.160.524
1t3r017Gag-Pol polyprotein3.4.23.160.524
2qnqQN3Gag-Pol polyprotein3.4.23.160.524
3cktYDPGag-Pol polyprotein3.4.23.160.524
3dckKVIProtease/0.524
1bv7XV6Gag-Pol polyprotein3.4.23.160.523
1d4kPI8Gag-Pol polyprotein3.4.23.160.523
1sdtMK1Gag-Pol polyprotein3.4.23.160.523
2q641UNGag-Pol polyprotein3.4.23.160.523
3bxrDRRGag-Pol polyprotein3.4.23.160.523
1hpxKNIGag-Pol polyprotein/0.522
2qci065Gag-Pol polyprotein3.4.23.160.522
2rkfAB1Pol protein/0.522
3qrmNK7Gag-Pol polyprotein3.4.23.160.522
4hegG52Gag-Pol polyprotein3.4.23.160.522
1a8g2Z4Gag-Pol polyprotein3.4.23.160.521
1fg62NCGag-Pol polyprotein3.4.23.160.521
1tcxIM1Gag-Pol polyprotein3.4.23.160.521
2f80017Gag-Pol polyprotein3.4.23.160.521
4gb20LQGag-Pol polyprotein2.7.7.490.521
2qhcAB1Protease/0.520
3nuo478Gag-Pol polyprotein3.4.23.160.520
3ufnROCGag-Pol polyprotein/0.520
1fff0Q4Gag-Pol polyprotein3.4.23.160.519
2qak1UNGag-Pol polyprotein3.4.23.160.519
2qhyMZ1Gag-Pol polyprotein/0.519
3o9gF53Gag-Pol polyprotein/0.519
3s54017Protease/0.519
4q1y017Gag-Pol polyprotein3.4.23.160.519
1g35AHFGag-Pol polyprotein3.4.23.160.518
2cej1AHPol protein/0.518
2f8g017Gag-Pol polyprotein3.4.23.160.518
2q3kMUWGag-Pol polyprotein/0.518
2r5pMK1Gag-Pol polyprotein/0.518
3ekx1UNGag-Pol polyprotein3.4.23.160.518
4a6cQG9Gag-Pol polyprotein3.4.23.160.518
4dfg0JVGag-Pol polyprotein3.4.23.160.518
1ec0BEDGag-Pol polyprotein3.4.23.160.517
1npa3NHGag-Pol polyprotein3.4.23.160.517
1npwLGZGag-Pol polyprotein3.4.23.160.517
1w5vBE3Gag-Pol polyprotein3.4.23.160.517
2qi7MZ9Gag-Pol polyprotein/0.517
2qnnQN1Gag-Pol polyprotein3.4.23.160.516
3ekv478Gag-Pol polyprotein3.4.23.160.516
3toh079Gag-Pol polyprotein2.7.7.490.516
4njsG08Protease/0.516
3bvb017Gag-Pol polyprotein3.4.23.160.515
3fx5KNIGag-Pol polyprotein3.4.23.160.515
3tof076Gag-Pol polyprotein2.7.7.490.515
4j5j478Gag-Pol polyprotein3.4.23.160.515
1c6x3INProtease/0.514
1c70L75Protease/0.514
1hsgMK1Gag-Pol polyprotein/0.514
1t7kBH0Gag-Pol polyprotein3.4.23.160.514
2fxdDR7Pol polyprotein/0.514
2hb3GRLProtease/0.514
2hc0AB2Protease/0.514
3djkG55Gag-Pol polyprotein3.4.23.160.514
3vf7031Gag-Pol polyprotein3.4.23.160.514
1ebyBEBGag-Pol polyprotein3.4.23.160.513
2b60RITPol polyprotein/0.513
2bb9AKCGag-Pol polyprotein3.4.23.160.513
2qi0MZ3Gag-Pol polyprotein/0.513
2r5q1UNGag-Pol polyprotein/0.513
3gi5K62Gag-Pol polyprotein/0.513
3qroNK9Gag-Pol polyprotein3.4.23.160.513
1muiAB1Protease/0.512
1sguMK1Gag-Pol polyprotein3.4.23.160.512
4dqh017Gag-Pol polyprotein/0.512
1b6kPI5Gag-Pol polyprotein3.4.23.160.511
1hiiC20Gag-Pol polyprotein/0.511
1d4lPI9Gag-Pol polyprotein3.4.23.160.510
3mws017Pol protein/0.510
1bdrIM1Gag-Pol polyprotein3.4.23.160.509
2pym1UNGag-Pol polyprotein3.4.23.160.509
3oxw017Gag-Pol polyprotein3.4.23.160.509
1d4jMSCGag-Pol polyprotein3.4.23.160.508
3i6oGR6Gag-Pol polyprotein3.4.23.160.508
3kddJZQGag-Pol polyprotein3.4.23.160.508
3o9dK19Pol polyprotein/0.508
1bai0Q4Gag-Pro polyprotein/0.507
2avsMK1Gag-Pol polyprotein3.4.23.160.507
2psuMUUProtease/0.507
2psvMUVProtease/0.507
4njuTPVProtease/0.507
1hshMK1Gag-Pol polyprotein/0.506
3ggu017Gag-Pol polyprotein3.4.23.160.506
3o9iA61Gag-Pol polyprotein/0.506
3qpjN4IGag-Pol polyprotein3.4.23.160.506
4k4p3TLGag-Pol polyprotein/0.506
7upjINUGag-Pol polyprotein3.4.23.160.506
1bwaXV6Gag-Pol polyprotein3.4.23.160.505
1meuDMPGag-Pol polyprotein3.4.23.160.505
1qbu846Gag-Pol polyprotein3.4.23.160.505
2hs2017Protease/0.505
2i4wKGQProtease/0.505
2pqzG0GGag-Pol polyprotein3.4.23.160.505
3lzs017Gag-Pol polyprotein3.4.23.160.505
3nu4478Gag-Pol polyprotein3.4.23.160.505
1sduMK1Gag-Pol polyprotein3.4.23.160.504
2i4uDJRProtease/0.504
3qp0NI8Gag-Pol polyprotein3.4.23.160.504
3sa8K83Protease/0.504
1kzkJE2Gag-Pol polyprotein3.4.23.160.503
2q631UNGag-Pol polyprotein3.4.23.160.503
2qhzMZ2Gag-Pol polyprotein/0.503
3qaaG04Gag-Pol polyprotein3.4.23.160.503
3saa77FProtease/0.503
4dqb017Gag-Pol polyprotein/0.503
2aidTHKGag-Pol polyprotein3.4.23.160.502
2r43G3GGag-Pol polyprotein3.4.23.160.502
4i8zG08Gag-Pol polyprotein3.4.23.160.502
4njt017Protease/0.502
3nls016Gag-Pol polyprotein3.4.23.160.501
9hvp0E9Gag-Pol polyprotein/0.501
2z54AB1Gag-Pol polyprotein3.4.23.160.500
3liqE14Protease/0.500
3livE16Protease/0.500
3nu6478Gag-Pol polyprotein3.4.23.160.500
1qbrXV6Gag-Pol polyprotein3.4.23.160.499
1tcwIM1Gag-Pol polyprotein/0.499
3bgbLJGGag-Pol polyprotein3.4.23.160.499
3s43478Protease/0.499
1hpoUNIGag-Pol polyprotein3.4.23.160.498
1bwb146Gag-Pol polyprotein3.4.23.160.497
2qi1MZ4Gag-Pol polyprotein/0.497
2qi4MZ6Gag-Pol polyprotein/0.497
3d1z017Gag-Pol polyprotein3.4.23.160.497
3t3c017Gag-Pol polyprotein3.4.23.160.497
1k2c0Q4Gag-Pol polyprotein3.4.23.160.496
3cyw017Gag-Pol polyprotein3.4.23.160.496
3o9hK2EGag-Pol polyprotein/0.496
2p3a3TLPol protein/0.495
3bheBZNGag-Pol polyprotein3.4.23.160.495
3lzu017Gag-Pol polyprotein3.4.23.160.495
3nwxKVSGag-Pol polyprotein3.4.23.160.495
3ucb017Gag-Pol polyprotein/0.495
1ivq0PXGag-Pol polyprotein/0.494
2z4o065Gag-Pol polyprotein3.4.23.160.494
3em3478Gag-Pol polyprotein3.4.23.160.494
1bdlIM1Gag-Pol polyprotein3.4.23.160.493
1d4hBEHGag-Pol polyprotein3.4.23.160.493
1qbt146Gag-Pol polyprotein3.4.23.160.493
1sh9RITGag-Pol polyprotein3.4.23.160.493
3i7eDJRGag-Pol polyprotein/0.493
3t113T1Gag-Pol polyprotein3.4.23.160.493
3uhl2NCGag-Pol polyprotein3.4.23.160.493
1ajxAH1Gag-Pol polyprotein3.4.23.160.492
1bdqIM1Gag-Pol polyprotein3.4.23.160.492
2i4vDJRV-1 protease/0.491
3o99K13Pol polyprotein/0.491
1g2kNM1Gag-Pol polyprotein3.4.23.160.490
1qbsDMPGag-Pol polyprotein3.4.23.160.490
1sivPSIGag-Pol polyprotein/0.490
2i0dMUTProtease/0.490
3qihNI7Gag-Pol polyprotein3.4.23.160.490
2p3c3TLProtease/0.489
3lzv017Gag-Pol polyprotein3.4.23.160.489
4q1w017Gag-Pol polyprotein3.4.23.160.489
1c6yMK1Protease/0.488
1hpv478Gag-Pol polyprotein/0.488
3qihFG7Gag-Pol polyprotein3.4.23.160.488
2i4dQFIProtease/0.487
3bgcLJHGag-Pol polyprotein3.4.23.160.487
2q55MU0Protease/0.486
4dqf017Gag-Pol polyprotein/0.486
3litE15Protease/0.484
1hwr216Gag-Pol polyprotein3.4.23.160.483
3pwm017Gag-Pol polyprotein3.4.23.160.483
1ajvNMBGag-Pol polyprotein3.4.23.160.482
1msmJE2Gag-Pol polyprotein3.4.23.160.482
3aidARQGag-Pol polyprotein3.4.23.160.482
1mesDMPGag-Pol polyprotein3.4.23.160.480
1proA88Gag-Pol polyprotein/0.480
3mxdK53Gag-Pol polyprotein3.4.23.160.480
1ebk0Q4Gag-Pol polyprotein3.4.23.160.479
1t7j478Gag-Pol polyprotein3.4.23.160.479
2bpxMK1Gag-Pol polyprotein3.4.23.160.479
3r4b74TGag-Pol polyprotein/0.479
4hla017Gag-Pol polyprotein3.4.23.160.479
3d20017Gag-Pol polyprotein3.4.23.160.478
2r3tG4GGag-Pol polyprotein3.4.23.160.477
3nu5478Gag-Pol polyprotein3.4.23.160.476
4j54G52Gag-Pol polyprotein3.4.23.160.476
1mrwK57Gag-Pol polyprotein3.4.23.160.475
2bbbHH1Gag-Pol polyprotein3.4.23.160.475
2r3wG3GGag-Pol polyprotein3.4.23.160.475
3ecg065Gag-Pol polyprotein3.4.23.470.474
3upjU03Gag-Pol polyprotein/0.474
1hbvGANGag-Pol polyprotein/0.473
1odyLP1Gag-Pol polyprotein3.4.23.160.473
3ec0GRLGag-Pol polyprotein3.4.23.470.473
2pwcG3GGag-Pol polyprotein3.4.23.160.472
3el01UNGag-Pol polyprotein3.4.23.160.472
2i0aMUIProtease/0.470
1bv9XV6Gag-Pol polyprotein3.4.23.160.469
2r38G4GGag-Pol polyprotein3.4.23.160.469
1merDMQGag-Pol polyprotein3.4.23.160.468
2hs1017Protease/0.468
3nuj478Gag-Pol polyprotein3.4.23.160.468
1dmpDMQGag-Pol polyprotein3.4.23.160.467
3o9aK14Pol polyprotein/0.467
4q1x017Gag-Pol polyprotein3.4.23.160.467
3nu3478Gag-Pol polyprotein3.4.23.160.460
3wsjMK1Protease/0.460
6upjNIUGag-Pol polyprotein/0.454
3so9017Pol protein/0.452
1npvL27Gag-Pol polyprotein3.4.23.160.450
1k6pXN3Gag-Pol polyprotein3.4.23.160.449
2pwrG4GGag-Pol polyprotein3.4.23.160.448
3lixE17Protease/0.448
1xl2189Gag-Pol polyprotein3.4.23.160.442