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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.91.000
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.592
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.581
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.556
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.553
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.543
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.542
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.538
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.524
1gerFADGlutathione reductase1.8.1.70.507
2rabFADGlutathione amide reductase/0.495
1geuFADGlutathione reductase1.8.1.70.493
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.492
1onfFADGlutathione reductase1.8.1.70.484
1getFADGlutathione reductase1.8.1.70.482
1greFADGlutathione reductase, mitochondrial1.8.1.70.473
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.464
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.463
1feaFADTrypanothione reductase1.8.1.120.451
3djgFADGlutathione reductase, mitochondrial1.8.1.70.450
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.443
1h7wFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.440