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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cokANPSerine/threonine-protein kinase PLK42.7.11.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3cokANPSerine/threonine-protein kinase PLK42.7.11.211.000
4o0uADNAurora kinase A2.7.11.10.529
2c6eHPMAurora kinase A2.7.11.10.524
4c3pACPAurora kinase A2.7.11.10.517
4jboWPHAurora kinase A2.7.11.10.507
3ztxZTXAurora kinase B-A2.7.11.10.503
4jbpYPHAurora kinase A2.7.11.10.497
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.486
3k5uPFQAurora kinase A2.7.11.10.483
2wqeADPAurora kinase A2.7.11.10.482
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.481
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.480
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.479
4qmlANPSerine/threonine-protein kinase 242.7.11.10.477
2qocANPEphrin type-A receptor 32.7.10.10.472
2j7t274Serine/threonine-protein kinase 102.7.11.10.471
2j0lANPFocal adhesion kinase 12.7.10.20.470
1i44ACPInsulin receptor2.7.10.10.469
2vrx447Aurora kinase B-A2.7.11.10.469
2qoqANPEphrin type-A receptor 32.7.10.10.468
1mqbANPEphrin type-A receptor 22.7.10.10.466
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.466
2ijmATPFocal adhesion kinase 12.7.10.20.464
2qo7ANPEphrin type-A receptor 32.7.10.10.464
3c4xATPRhodopsin kinase/0.464
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.461
4jia1K3Tyrosine-protein kinase JAK2/0.459
3c4wATPRhodopsin kinase/0.458
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.456
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.453
4c4f7CEDual specificity protein kinase TTK2.7.12.10.452
4k8aK8AFocal adhesion kinase 12.7.10.20.452
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.451
2henADPEphrin type-B receptor 22.7.10.10.450
3zxtACPDeath-associated protein kinase 12.7.11.10.450
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.450
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.448
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
3c4zADPRhodopsin kinase/0.447
4c4h7RODual specificity protein kinase TTK2.7.12.10.447
5av3KMPDeath-associated protein kinase 12.7.11.10.446
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.445
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.445
2vgpAD6Aurora kinase B-A2.7.11.10.444
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.441
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.441
4l9i8PRRhodopsin kinase/0.441
3d7tSTUTyrosine-protein kinase CSK/0.440
3erkSB4Mitogen-activated protein kinase 12.7.11.240.440