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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2z2w770Wee1-like protein kinase2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2z2w770Wee1-like protein kinase2.7.10.21.000
2in6839Wee1-like protein kinase2.7.10.20.767
2io6330Wee1-like protein kinase2.7.10.20.730
3biz61EWee1-like protein kinase2.7.10.20.660
1x8b824Wee1-like protein kinase2.7.10.20.657
3cqeP91Wee1-like protein kinase2.7.10.20.646
3cr0809Wee1-like protein kinase2.7.10.20.630
3bi6396Wee1-like protein kinase2.7.10.20.618
2yac937Serine/threonine-protein kinase PLK12.7.11.210.513
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.493
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.489
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.488
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.480
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.479
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.479
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.476
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.473
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.471
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.470
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.469
3zh8C58Protein kinase C iota type2.7.11.130.465
2hog710Serine/threonine-protein kinase Chk12.7.11.10.464
2owb626Serine/threonine-protein kinase PLK12.7.11.210.462
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.462
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.461
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.459
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.458
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.457
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.456
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.454
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.453
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.452
4qnaX11Serine/threonine-protein kinase 242.7.11.10.452
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.450
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.450
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.450
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.449
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.447
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3zewSTUEphrin type-B receptor 42.7.10.10.446
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.445
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.445
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.445
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.444
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.444
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.443
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.443
3at4CCKCasein kinase II subunit alpha2.7.11.10.443
4gmy0X5Tyrosine-protein kinase JAK2/0.443
3zep1NXTyrosine-protein kinase JAK32.7.10.20.442
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.442
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.442
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.441
4dgo0JWCasein kinase II subunit alpha2.7.11.10.441
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.440
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.440