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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ye42FYHeat shock protein HSP 90-alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ye42FYHeat shock protein HSP 90-alpha/1.000
2bsmBSMHeat shock protein HSP 90-alpha/0.661
2vci2GJHeat shock protein HSP 90-alpha/0.622
2yecXQ0Heat shock protein HSP 90-alpha/0.615
4egh0OYHeat shock protein HSP 90-alpha/0.614
2wi5ZZ5Heat shock protein HSP 90-alpha/0.574
2wi1ZZ2Heat shock protein HSP 90-alpha/0.569
2yi66QMHeat shock protein HSP 90-alpha/0.551
2uwd2GGHeat shock protein HSP 90-alpha/0.542
2vcj2EQHeat shock protein HSP 90-alpha/0.538
3hyz42CHeat shock protein HSP 90-alpha/0.532
4fcq2N6Heat shock protein HSP 90-alpha/0.522
2yjwYJWHeat shock protein HSP 90-alpha/0.521
4ipeANPTNF receptor-associated protein 1/0.521
2ye92D4Heat shock protein HSP 90-alpha/0.514
4bqg50QHeat shock protein HSP 90-alpha/0.501
2qg0A94Heat shock protein HSP 90-alpha/0.499
2ccu2D9Heat shock protein HSP 90-alpha/0.496
2wi2ZZ3Heat shock protein HSP 90-alpha/0.496
1yc14BCHeat shock protein HSP 90-alpha/0.493
3d0bSNXHeat shock protein HSP 90-alpha/0.490
3k974CDHeat shock protein HSP 90-alpha/0.489
4ivgANPTNF receptor-associated protein 1/0.488
4egkRDCHeat shock protein HSP 90-alpha/0.483
1yc443PHeat shock protein HSP 90-alpha/0.478
2bz5AB4Heat shock protein HSP 90-alpha/0.475
2yegXQGHeat shock protein HSP 90-alpha/0.473
2cct2E1Heat shock protein HSP 90-alpha/0.469
2xcmADPCytosolic heat shock protein 90/0.468
2yi7BZ8Heat shock protein HSP 90-alpha/0.467
4jqlVJ6Heat shock protein HSP 90-alpha/0.466
1yc34BCHeat shock protein HSP 90-alpha/0.463
2yeiXQIHeat shock protein HSP 90-alpha/0.463
4xcjADPHeat shock cognate 90 kDa protein/0.463
3opdHIEHeat shock protein 83/0.462
1uy9PU6Heat shock protein HSP 90-alpha/0.461
3rlq3RQHeat shock protein HSP 90-alpha/0.456
1osfKOSHeat shock protein HSP 90-alpha/0.455
4xclAGSHeat shock cognate 90 kDa protein/0.451
1yetGDMHeat shock protein HSP 90-alpha/0.450
3qdd94MHeat shock protein HSP 90-alpha/0.448
2bt0CT5Heat shock protein HSP 90-alpha/0.445
3ft5MO8Heat shock protein HSP 90-alpha/0.444
2byi2DDHeat shock protein HSP 90-alpha/0.440