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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2x7eX7EKinesin-like protein KIF11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2x7eX7EKinesin-like protein KIF11/1.000
2x7dEGBKinesin-like protein KIF11/0.619
2iehMOYKinesin-like protein KIF11/0.612
3k5eK5EKinesin-like protein KIF11/0.606
2g1qN9HKinesin-like protein KIF11/0.599
1x88NATKinesin-like protein KIF11/0.596
2x2rX2OKinesin-like protein KIF11/0.596
2xae2XAKinesin-like protein KIF11/0.589
4bbgV02Kinesin-like protein KIF11/0.587
1q0bNATKinesin-like protein KIF11/0.581
2q2zMKKKinesin-like protein KIF11/0.577
2wogZZDKinesin-like protein KIF11/0.576
3k3bL31Kinesin-like protein KIF11/0.560
2fme3QCKinesin-like protein KIF11/0.545
3kenZZDKinesin-like protein KIF11/0.541
2gm12AZKinesin-like protein KIF11/0.520
4a51DQ8Kinesin-like protein KIF11/0.506
4a5yG7XKinesin-like protein KIF11/0.480
4as76LXKinesin-like protein KIF11/0.462
3bhtMFRCyclin-dependent kinase 22.7.11.220.461
4bcqTJFCyclin-dependent kinase 22.7.11.220.456
1w2xRCPAcetyl-CoA carboxylase/0.455
2itxANPEpidermal growth factor receptor2.7.10.10.455
2wi1ZZ2Heat shock protein HSP 90-alpha/0.455
2vwqNAPGlucose 1-dehydrogenase/0.453
1fvt106Cyclin-dependent kinase 22.7.11.220.452
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
3qx4X4BCyclin-dependent kinase 22.7.11.220.451
4bcpT3CCyclin-dependent kinase 22.7.11.220.451
1vyzN5BCyclin-dependent kinase 22.7.11.220.450
3qqlX03Cyclin-dependent kinase 22.7.11.220.448
1ckpPVBCyclin-dependent kinase 22.7.11.220.447
2zcePYLPyrrolysine--tRNA ligase/0.447
4eomATPCyclin-dependent kinase 22.7.11.220.447
1h1r6CPCyclin-dependent kinase 22.7.11.220.446
1f20FADNitric oxide synthase, brain1.14.13.390.445
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.445
4z34ON7Lysophosphatidic acid receptor 1/0.445
1oguST8Cyclin-dependent kinase 22.7.11.220.444
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.444
3b9lAZZSerum albumin/0.443
2bkzSBCCyclin-dependent kinase 22.7.11.220.442
2p1v5TNRetinoic acid receptor RXR-alpha/0.442
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
3lfqA28Cyclin-dependent kinase 22.7.11.220.441
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4jq7KJQEpidermal growth factor receptor2.7.10.10.441
1oiuN76Cyclin-dependent kinase 22.7.11.220.440
2eb3ANPEpidermal growth factor receptor2.7.10.10.440
2vci2GJHeat shock protein HSP 90-alpha/0.440
3flsFLSMitogen-activated protein kinase 14/0.440
3k47D09Dihydrofolate reductase1.5.1.30.440
4hy6FJ1Heat shock protein HSP 90-alpha/0.440