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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wgjVGHHepatocyte growth factor receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2wgjVGHHepatocyte growth factor receptor2.7.10.11.000
4gg70J8Hepatocyte growth factor receptor2.7.10.10.628
3zze6XPHepatocyte growth factor receptor2.7.10.10.622
4ap7F47Hepatocyte growth factor receptor2.7.10.10.592
3a4pDFQHepatocyte growth factor receptor2.7.10.10.575
4deg0JJHepatocyte growth factor receptor2.7.10.10.568
4gg50J3Hepatocyte growth factor receptor2.7.10.10.549
3zxzKRWHepatocyte growth factor receptor2.7.10.10.543
4aoi4K0Hepatocyte growth factor receptor2.7.10.10.531
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.529
2xikJ60Serine/threonine-protein kinase 252.7.11.10.487
3zbx6XEHepatocyte growth factor receptor2.7.10.10.483
1u4dDBQActivated CDC42 kinase 1/0.474
5e8wSTUTGF-beta receptor type-12.7.11.300.474
5cwa0GAAnthranilate synthase component 14.1.3.270.472
2b7aIZATyrosine-protein kinase JAK2/0.466
4qmpDKISerine/threonine-protein kinase 242.7.11.10.462
1vjy460TGF-beta receptor type-12.7.11.300.461
3s1dZIRCytokinin dehydrogenase 11.5.99.120.461
4dgo0JWCasein kinase II subunit alpha2.7.11.10.459
3iok1P6Tyrosine-protein kinase JAK2/0.458
4iwd1JCHepatocyte growth factor receptor2.7.10.10.458
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.457
4dymIYZActivin receptor type-12.7.11.300.456
2uzlC94Cyclin-dependent kinase 22.7.11.220.455
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.455
1h1s4SPCyclin-dependent kinase 22.7.11.220.454
1rx8FOLDihydrofolate reductase1.5.1.30.453
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.453
5drdATPAurora kinase A2.7.11.10.453
1ir3ANPInsulin receptor2.7.10.10.450
1oi9N20Cyclin-dependent kinase 22.7.11.220.450
1u54ACPActivated CDC42 kinase 1/0.450
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.450
1q1rFADPutidaredoxin reductase1.18.1.50.449
3nr4PYVAbscisic acid receptor PYL2/0.449
4c02TAKActivin receptor type-12.7.11.300.448
1py5PY1TGF-beta receptor type-12.7.11.300.447
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.447
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.447
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.447
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.446
1g5sI17Cyclin-dependent kinase 22.7.11.220.445
1xjdSTUProtein kinase C theta type2.7.11.130.445
2wotZZGTGF-beta receptor type-12.7.11.300.445
2x1nX1NCyclin-dependent kinase 22.7.11.220.445
3gwfFADCyclohexanone monooxygenase/0.445
4erwSTUCyclin-dependent kinase 22.7.11.220.444
3l0lHC3Nuclear receptor ROR-gamma/0.443
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.443
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.443
1oguST8Cyclin-dependent kinase 22.7.11.220.442
1oirHDYCyclin-dependent kinase 22.7.11.220.442
3i81EBIInsulin-like growth factor 1 receptor2.7.10.10.442
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.441
2w1gL0GAurora kinase A2.7.11.10.441
3bhtMFRCyclin-dependent kinase 22.7.11.220.441
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.441
4a8v2ANMajor pollen allergen Bet v 1-J/0.441
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.441
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.441
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.440
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.440