scPDB - Distribution of Cavity Similarity values of 2w17 entry / Site 1

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2w17	I19	Cyclin-dependent kinase 2	2.7.11.22

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
2w17	I19	Cyclin-dependent kinase 2	2.7.11.22	1.000
2vv9	IM9	Cyclin-dependent kinase 2	2.7.11.22	0.598
3s1h	56Z	Cyclin-dependent kinase 2	2.7.11.22	0.583
3ezv	EZV	Cyclin-dependent kinase 2	2.7.11.22	0.569
3rak	03Z	Cyclin-dependent kinase 2	2.7.11.22	0.557
2r3j	SCJ	Cyclin-dependent kinase 2	2.7.11.22	0.555
3qxp	X64	Cyclin-dependent kinase 2	2.7.11.22	0.542
1fvv	107	Cyclin-dependent kinase 2	2.7.11.22	0.539
3rkb	12Z	Cyclin-dependent kinase 2	2.7.11.22	0.526
2w05	FRT	Cyclin-dependent kinase 2	2.7.11.22	0.522
4fkv	61K	Cyclin-dependent kinase 2	2.7.11.22	0.522
1gii	1PU	Cyclin-dependent kinase 2	2.7.11.22	0.520
4fkt	48K	Cyclin-dependent kinase 2	2.7.11.22	0.513
3nux	3NV	Cyclin-dependent kinase 6	2.7.11.22	0.503
4ez5	0RS	Cyclin-dependent kinase 6	2.7.11.22	0.503
2fvd	LIA	Cyclin-dependent kinase 2	2.7.11.22	0.499
2vu3	LZE	Cyclin-dependent kinase 2	2.7.11.22	0.494
3ofm	4B0	Casein kinase II subunit alpha'	2.7.11.1	0.488
1pxm	CK5	Cyclin-dependent kinase 2	2.7.11.22	0.485
4fkg	4CK	Cyclin-dependent kinase 2	2.7.11.22	0.480
4grb	0XG	Casein kinase II subunit alpha	2.7.11.1	0.478
2uzb	C75	Cyclin-dependent kinase 2	2.7.11.22	0.477
1ke5	LS1	Cyclin-dependent kinase 2	2.7.11.22	0.472
2vth	LZ2	Cyclin-dependent kinase 2	2.7.11.22	0.472
3lfn	A27	Cyclin-dependent kinase 2	2.7.11.22	0.472
1oir	HDY	Cyclin-dependent kinase 2	2.7.11.22	0.471
2c6l	DT4	Cyclin-dependent kinase 2	2.7.11.22	0.471
3q9x	EMO	Casein kinase II subunit alpha	2.7.11.1	0.471
2bts	U32	Cyclin-dependent kinase 2	2.7.11.22	0.470
2c6o	4SP	Cyclin-dependent kinase 2	2.7.11.22	0.467
1g5s	I17	Cyclin-dependent kinase 2	2.7.11.22	0.465
3lfq	A28	Cyclin-dependent kinase 2	2.7.11.22	0.465
2pvl	P55	Casein kinase II subunit alpha	2.7.11.1	0.464
2r3k	SCQ	Cyclin-dependent kinase 2	2.7.11.22	0.464
1pxl	CK4	Cyclin-dependent kinase 2	2.7.11.22	0.463
2vtj	LZ4	Cyclin-dependent kinase 2	2.7.11.22	0.463
2j9m	PY8	Cyclin-dependent kinase 2	2.7.11.22	0.462
4bcm	T7Z	Cyclin-dependent kinase 2	2.7.11.22	0.462
2uzd	C85	Cyclin-dependent kinase 2	2.7.11.22	0.461
2xmy	CDK	Cyclin-dependent kinase 2	2.7.11.22	0.461
2uzn	C96	Cyclin-dependent kinase 2	2.7.11.22	0.460
2vtp	LZ9	Cyclin-dependent kinase 2	2.7.11.22	0.459
4btj	ATP	Tau-tubulin kinase 1	2.7.11.1	0.459
4fks	46K	Cyclin-dependent kinase 2	2.7.11.22	0.458
1pxp	CK8	Cyclin-dependent kinase 2	2.7.11.22	0.457
2c6i	DT1	Cyclin-dependent kinase 2	2.7.11.22	0.457
3rjc	06Z	Cyclin-dependent kinase 2	2.7.11.22	0.457
4dgm	AGI	Casein kinase II subunit alpha	2.7.11.1	0.457
3at4	CCK	Casein kinase II subunit alpha	2.7.11.1	0.456
2r3l	SCW	Cyclin-dependent kinase 2	2.7.11.22	0.455
3r8l	Z30	Cyclin-dependent kinase 2	2.7.11.22	0.455
1oit	HDT	Cyclin-dependent kinase 2	2.7.11.22	0.453
2btr	U73	Cyclin-dependent kinase 2	2.7.11.22	0.453
3r1y	X76	Cyclin-dependent kinase 2	2.7.11.22	0.453
3rmf	20Z	Cyclin-dependent kinase 2	2.7.11.22	0.453
4bgh	3I6	Cyclin-dependent kinase 2	2.7.11.22	0.453
2b53	D23	Cyclin-dependent kinase 2	2.7.11.22	0.452
3rk7	08Z	Cyclin-dependent kinase 2	2.7.11.22	0.452
1w0x	OLO	Cyclin-dependent kinase 2	2.7.11.22	0.450
2pvm	P29	Casein kinase II subunit alpha	2.7.11.1	0.450
2vtt	LZD	Cyclin-dependent kinase 2	2.7.11.22	0.450
1pxo	CK7	Cyclin-dependent kinase 2	2.7.11.22	0.449
3sw7	19K	Cyclin-dependent kinase 2	2.7.11.22	0.448
4ii5	ADP	Cyclin-dependent kinase 2	2.7.11.22	0.448
3ral	04Z	Cyclin-dependent kinase 2	2.7.11.22	0.447
3rah	O1Z	Cyclin-dependent kinase 2	2.7.11.22	0.446
4fkq	42K	Cyclin-dependent kinase 2	2.7.11.22	0.446
4j95	ACP	Fibroblast growth factor receptor 2	/	0.446
3axw	TID	Casein kinase II subunit alpha	2.7.11.1	0.445
4ek6	10K	Cyclin-dependent kinase 2	2.7.11.22	0.445
2pvh	P19	Casein kinase II subunit alpha	2.7.11.1	0.444
3nyn	SGV	G protein-coupled receptor kinase 6	2.7.11.16	0.444
2r3p	3SC	Cyclin-dependent kinase 2	2.7.11.22	0.443
4dgn	LU2	Casein kinase II subunit alpha	2.7.11.1	0.443
1ykr	628	Cyclin-dependent kinase 2	2.7.11.22	0.442
3zc6	VFC	Tyrosine-protein kinase JAK3	2.7.10.2	0.442
2r3i	SCF	Cyclin-dependent kinase 2	2.7.11.22	0.441
3fz1	B98	Cyclin-dependent kinase 2	2.7.11.22	0.441
3qtr	X36	Cyclin-dependent kinase 2	2.7.11.22	0.441
3s2p	PMU	Cyclin-dependent kinase 2	2.7.11.22	0.440