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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2tprFADTrypanothione reductase1.8.1.12

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2tprFADTrypanothione reductase1.8.1.121.000
1tytFADTrypanothione reductase1.8.1.120.633
2jk6FADTrypanothione reductase/0.607
4dnaFADProbable glutathione reductase/0.602
1fecFADTrypanothione reductase1.8.1.120.583
2hqmFADGlutathione reductase1.8.1.70.574
1gxfFADTrypanothione reductase1.8.1.120.564
1bzlFADTrypanothione reductase1.8.1.120.563
4nevFADTrypanothione reductase/0.559
1dncFADGlutathione reductase, mitochondrial1.8.1.70.557
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.556
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.90.551
4la1FADThioredoxin glutathione reductase/0.543
2x8gFADThioredoxin glutathione reductase/0.532
4j57FADThioredoxin reductase 21.8.1.90.527
2x8hFADThioredoxin glutathione reductase/0.515
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.514
1gerFADGlutathione reductase1.8.1.70.513
2wbaFADTrypanothione reductase1.8.1.120.503
4b1bFADThioredoxin reductase1.8.1.90.501
4em3FADCoenzyme A disulfide reductase/0.498
4eqxFADCoenzyme A disulfide reductase/0.477
1yqzFADCoenzyme A disulfide reductase/0.467
3ntdFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.467
4eqwFADCoenzyme A disulfide reductase/0.459
4eqsFADCoenzyme A disulfide reductase/0.444