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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qoqANPEphrin type-A receptor 32.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2qoqANPEphrin type-A receptor 32.7.10.11.000
2henADPEphrin type-B receptor 22.7.10.10.632
2qo7ANPEphrin type-A receptor 32.7.10.10.582
4gk4L90Ephrin type-A receptor 32.7.10.10.515
2qocANPEphrin type-A receptor 32.7.10.10.513
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.491
3zewSTUEphrin type-B receptor 42.7.10.10.481
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.477
2xvdAS6Ephrin type-B receptor 42.7.10.10.476
2qo9ANPEphrin type-A receptor 32.7.10.10.466
4c3pACPAurora kinase A2.7.11.10.464
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.464
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.462
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.460
4gk3L87Ephrin type-A receptor 32.7.10.10.458
4qmlANPSerine/threonine-protein kinase 242.7.11.10.458
3c4wATPRhodopsin kinase/0.457
4qnyANPMitogen activated protein kinase, putative/0.457
2j0lANPFocal adhesion kinase 12.7.10.20.456
2ijmATPFocal adhesion kinase 12.7.10.20.454
3bu5ATPInsulin receptor2.7.10.10.453
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
4jia1K3Tyrosine-protein kinase JAK2/0.444
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.443
3qc9ADPRhodopsin kinase/0.442
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.441
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.441
5eg3ACPFibroblast growth factor receptor 2/0.441
2x9fX9FEphrin type-B receptor 42.7.10.10.440