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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ibyCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ibyCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.91.000
2ibwCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.663
2ibuCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.613
1wl4COAAcetyl-CoA acetyltransferase, cytosolic2.3.1.90.484
2cgpCMPcAMP-activated global transcriptional regulator CRP/0.461
2j3qTFLAcetylcholinesterase3.1.1.70.458
4c2jCOA3-ketoacyl-CoA thiolase, mitochondrial2.3.1.160.457
3fvlBHKCarboxypeptidase A13.4.17.10.456
1pq944BOxysterols receptor LXR-beta/0.454
4i8vBHFCytochrome P450 1A11.14.14.10.453
4m6jNDPDihydrofolate reductase1.5.1.30.451
2ejjSAHDiphthine synthase/0.450
3w0hW12Vitamin D3 receptor/0.448
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.448
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.446
2ywlFADThioredoxin reductase related protein/0.444
1txiTX5Vitamin D3 receptor/0.443
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.443
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
1rx1NAPDihydrofolate reductase1.5.1.30.442
1culFOKAdenylate cyclase type 2/0.441
1culFOKAdenylate cyclase type 5/0.441
1h2bNAJNAD-dependent alcohol dehydrogenase/0.441
1mvsDTMDihydrofolate reductase1.5.1.30.441
2x7hPFNProstaglandin reductase 310.441
4l1xNAPAldo-keto reductase family 1 member C2/0.441
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.441
4rujVDXVitamin D3 receptor A/0.441
3w5p4OAVitamin D3 receptor/0.440
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4itfTFYVitamin D3 receptor/0.440
4kqqVPPPeptidoglycan D,D-transpeptidase FtsI/0.440